Evidence map›Paper›PMID 33316416›Full record

Trial reportJournal of pediatric and adolescent gynecology2021

Imaging Appearance of Nongerminoma Pediatric Ovarian Germ Cell Tumors Does Not Discriminate Benign from Malignant Histology.

Deborah Billmire, Bryan Dicken, Frederick Rescorla, Jonathan Ross, Jin Piao, Li Huang, Mark Krailo, Farzana Pashankar, Lindsay Frazier, Children's Oncology Group

Open access · greenAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of pediatric and adolescent gynecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Deborah BillmireDivision of Pediatric Surgery, Indiana University, Indianapolis, Indiana. Electronic address: dbillmir@iupui.edu.
Bryan DickenDivision of Pediatric Surgery, University of Alberta, Edmonton, Alberta, Canada.
Frederick RescorlaDivision of Pediatric Surgery, Indiana University, Indianapolis, Indiana.
Jonathan RossDepartment of Urology, Rush University, Chicago, Illinois.
Jin PiaoChildren's Oncology Group, Monrovia, California.
Li HuangChildren's Oncology Group, Monrovia, California.
Mark KrailoDepartment of Research Preventive Medicine, University of Southern California, Monrovia, California.
Farzana PashankarDepartment of Pediatrics, Yale School of Medicine, New Haven, Connecticut.
Lindsay FrazierDepartment of Pediatrics, Harvard University, Dana Farber Cancer Institute, Boston, Massachusetts.
Children's Oncology Group
Yale University · USChildren's Oncology Group · USRush University · USUniversity of Alberta · CA

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899
6 · The paper itself

Abstract

STUDY

objectivePediatric ovarian neoplasms with imaging appearance suggestive of teratoma are often presumed to have low risk of malignancy. We assessed the pre-operative imaging appearance of pediatric malignant ovarian germ cell tumors (MOGCT) and the presence of associated teratoma in a series of MOGCT.

designRetrospective review of clinical and pathology data.

settingMulticenter trial for extracranial malignant germ cell tumors in young female individuals by the Children's Oncology Group (COG study AGCT0132) that included yolk sac tumor, embryonal carcinoma and choriocarcinoma.

participantsFemale individuals 0-20 years of age at enrollment with ovarian primary nonseminomatous malignant germ cell tumors.

interventionsReview of data forms, including prospectively collected surgical checklist documenting imaging characteristics of the tumor, and review of pathology reports.

main outcome measuresDescription of imaging appearance and frequency of mixed histology with benign teratoma elements.

resultsA total of 138 female individuals (11 months to 20 years of age) had primary ovarian tumors. Imaging appearance and pathology information were available for 133 patients. Among the 133 patients, tumor appearance was solid (10.5%), solid with calcification (3.0%), mixed cystic and solid (58.7%), mixed cystic and solid with calcification (24.8%), and unknown (3.0%). In all, 54% had elements of teratoma in addition to malignant histology.

conclusionMixed cystic and solid appearance with or without calcification was seen in 83.5% of pediatric ovarian malignant germ cell tumors. Associated benign teratoma was common. The presence of a mixed cystic and solid appearance on preoperative imaging should not dissuade the surgeon from obtaining preoperative serum markers and undertaking complete surgical staging.

Indexed as

AdolescentChildChild, PreschoolDiagnostic ImagingFemaleHumansInfantNeoplasms, Germ Cell and EmbryonalOvarian NeoplasmsRetrospective StudiesTeratomaOvarian germ cell tumorsOvary yolk sac tumorTeratoma

Identifiers

PMID33316416
PMCPMC8096645
OpenAlexW3111062777

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.