Evidence map›Paper›PMID 33316227›Full record

Trial reportChemico-biological interactions2021

Thermovaccination - thermoheliox as a stimulator of the immune response. Kinetics of the synthesis of antibodies and C-reactive protein in coronavirus infection.

Sergey D Varfolomeev, Alexander A Panin, Valeriy I Bykov, Svetlana B Tsybenova, Sergey V Zhuravel, Anna M Ryabokon, Irina I Utkina, Pavel V Gavrilov, Sergey S Petrikov, Lyudmila V Shogenova and 1 more

Open access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Chemico-biological interactions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Thermoheliox: effect on the functional hemodynamics of the human brain.Russian chemical bulletin = Izvestiia Akademii nauk. Seriia khimicheskaia · 2022
    Article
  2. Intensive Care of Patients with COVID-19.Herald of the Russian Academy of Sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Sergey D VarfolomeevInstitute of Physicochemical Foundations of the Functioning of Neural Network and Artificial Intelligence, Moscow State University, Leninskie Gory, 1-11B, Moscow, 119991, Russia; Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia.
Alexander A PaninLLC "MedTechInnovations", Blagoveshchenskii per, 3-1, 123001, Russia.
Valeriy I BykovEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia.
Svetlana B TsybenovaEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia. Electronic address: s.tsybenova@gmail.com.
Sergey V ZhuravelN.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
Anna M RyabokonEmanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina, 4, Moscow, 119334, Russia; Department of Chemistry, Moscow State University, Leninskie Gory, 1-11B, Moscow, 119991, Russia.
Irina I UtkinaN.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
Pavel V GavrilovN.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
Sergey S PetrikovN.V. Sklifosovsky Federal Research Institute of Emergency Medicine, Bol'shaya Sukharevskaya Ploshchad', 3, 129090, Russia.
Lyudmila V ShogenovaN.I. Pirogov Russian State National Research Medical University, ul. Ostrovityanova, 1, Moscow, 117997, Russia.
Alexander G ChuchalinN.I. Pirogov Russian State National Research Medical University, ul. Ostrovityanova, 1, Moscow, 117997, Russia.
Research Institute of Emergency Care · RUInstitute of Biochemical Physics NM Emanuel · RUPirogov Russian National Research Medical University · RULomonosov Moscow State University · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical trials of thermoheliox application (inhalation with a high-temperature mixture of oxygen and helium, 90 °C) in the treatment of the acute phase of coronavirus infection were conducted. Dynamics of disease development in infected patients (PCR test for the virus) and, dynamics of changes in blood concentration of C-reactive protein, immunoglobulin M, specific immunoglobulin G were studied. High efficiency of thermoheliox in releasing the organism from the virus and stimulating the immune response (thermovaccination effect) was shown. The kinetic model of the process is proposed and analyzed.

Indexed as

Administration, InhalationAdultAgedAntibodies, ViralCOVID-19C-Reactive ProteinHeliumHot TemperatureHumansHyperthermia, InducedImmunoglobulin GImmunoglobulin MKineticsMiddle AgedModels, ImmunologicalOxygenAntibodies, ViralC-Reactive ProteinHeliumImmunoglobulin GImmunoglobulin MOxygenCoronavirusC-reactive proteinImmunoglobulin GKinetic modelPCR-TestThermoheliox

Identifiers

PMID33316227
PMCPMC7833474
OpenAlexW3112402394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.