Evidence map›Paper›PMID 33316141›Full record

ArticleMolecular oncology2021

A cancer-associated CDKN1B mutation induces p27 phosphorylation on a novel residue: a new mechanism for tumor suppressor loss-of-function.

Debora Bencivenga, Emanuela Stampone, Arianna Aulitto, Annunziata Tramontano, Clementina Barone, Aide Negri, Domenico Roberti, Silverio Perrotta, Fulvio Della Ragione, Adriana Borriello

Open access · goldAbstract read
In one paragraph

Article in Molecular oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. p27Cells · 2025
    Article
  8. Review
  9. p57International journal of molecular sciences · 2024
    Article
  10. Review
  11. Familial states of primary hyperparathyroidism: an update.Journal of endocrinological investigation · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. A Beckwith-Wiedemann-AssociatedInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Debora BencivengaDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID 0000-0003-0977-5374
Emanuela StamponeDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID 0000-0001-5828-1739
Arianna AulittoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Annunziata TramontanoDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Clementina BaroneDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.
Aide NegriDepartment of Medicine and Surgery, University of Parma, Italy.
Domenico RobertiDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Silverio PerrottaDepartment of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Fulvio Della RagioneDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID 0000-0002-0592-4283
Adriana BorrielloDepartment of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.ORCID 0000-0002-9026-8048
University of Campania "Luigi Vanvitelli" · ITUniversity of Parma · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CDKN1B haploinsufficiency promotes the development of several human cancers. The gene encodes p27

Indexed as

Genes, Tumor SuppressorLoss of Function MutationCell Line, TumorCyclin-Dependent Kinase Inhibitor p27HumansMutation, MissenseNeoplasmsPhosphorylationProtein Processing, Post-TranslationalCDKN1B protein, humanCyclin-Dependent Kinase Inhibitor p27CDK inhibitorshaploinsufficiencyp27 post-translational modificationstumor suppressor gene

Identifiers

PMID33316141
PMCPMC8024736
OpenAlexW3111731891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.