Evidence map›Paper›PMID 33315973›Full record

ArticleCanada communicable disease report = Releve des maladies transmissibles au Canada2020

Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of the current landscape of invasive meningococcal disease in children.

Joan L Robinson, Sergio Fanella, Alison Lopez, Craig Frankel, Jane McDonald, Mohammad Alghounaim, Robert Slinger, Jennifer Bowes, Sarah Khan, Jeannette L Comeau and 3 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canada communicable disease report = Releve des maladies transmissibles au Canada, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 1 country.

Joan L RobinsonDepartment of Pediatrics, University of Alberta, Edmonton, AB.
Sergio FanellaDepartment of Pediatrics, University of Manitoba, Winnipeg, MB.
Alison LopezDepartment of Pediatrics, University of Manitoba, Winnipeg, MB.
Craig FrankelDepartment of Paediatrics, Western University, London, ON.
Jane McDonaldDepartment of Pediatrics, McGill University, Montréal, QC.
Mohammad AlghounaimDepartment of Pediatrics, McGill University, Montréal, QC.
Robert SlingerDepartment of Pediatrics, University of Ottawa, Ottawa, ON.
Jennifer BowesDepartment of Pediatrics, University of Ottawa, Ottawa, ON.
Sarah KhanDepartment of Pediatrics, McMaster University, Hamilton, ON.
Jeannette L ComeauDepartment of Pediatrics, Dalhousie University, Halifax, NS.
Kirk LeifsoDepartment of Pediatrics, Queen's University, Kingston, ON.
John GunawanDepartment of Pediatrics, University of Alberta, Edmonton, AB.
Michelle BartonDepartment of Paediatrics, Western University, London, ON.
McGill University · CAUniversity of Alberta · CAUniversity of Manitoba · CAUniversity of Ottawa · CAWestern University · CADalhousie University · CAMcMaster University · CAQueen's University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundImmunizations have led to a decrease in the incidence of invasive meningococcal disease (IMD) in Canada, but this infection still leads to significant morbidity and mortality.

objectivesThe purpose of this study was to determine the burden of illness and management of IMD in paediatric hospitals.

methodsData were collected on all cases of IMD in eight paediatric hospitals from 2013 to 2017.

resultsThere were 17 cases of IMD. Three of eight hospitals had no cases. Just over half of the cases were serogroup B (n=9); a quarter (n=4) were serogroup W; less than a quarter (n=3) were serogroup Y; and one was unknown. Two infected children were not started on antibiotics until day one and day five after the initial blood culture was collected, but had uneventful recoveries. Six cases required admission to intensive care units; two died. Six cases had probable or proven meningitis. Thrombocytopenia was documented in seven cases. All cases had elevated C-reactive protein levels. Seven children received more than seven days of antibiotics; of these seven, only two had complications that justified prolonged therapy (subdural empyema and septic knee). Six cases had a central line placed.

conclusionIMD is now rare in Canadian children, but about one-third of the cases in our study required treatment in the intensive care unit and two died. Clinicians appear to not always be aware that a five to seven-day course is adequate for uncomplicated cases of bacteremia or meningitis.

Indexed as

IMDimmunizationmeningococcal diseaseserotype W

Identifiers

PMID33315973
PMCPMC7723307
OpenAlexW3093745608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.