Evidence map›Paper›PMID 33315949›Full record

ArticlePloS one2020

New trimester-specific reference intervals for clinical biochemical tests in Taiwanese pregnant women-cohort of TMICS.

Hui-Ming Chen, Fu-Chen Kuo, Chou-Cheng Chen, Chia-Fang Wu, Chien-Wen Sun, Mei-Lien Chen, Chia-Jung Hsieh, Shu-Li Wang, Ming-Tsang Wu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Hui-Ming ChenResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Fu-Chen KuoSchool of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
Chou-Cheng ChenResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chia-Fang WuResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Chien-Wen SunNational Environmental Health Research Center, National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.
Mei-Lien ChenInstitute of Environmental and Occupational Health Sciences, College of Medicine, National Yang Ming University, Taipei, Taiwan.
Chia-Jung HsiehDepartment of Public Health, Tzu Chi University, Hualien, Taiwan.
Shu-Li WangNational Environmental Health Research Center, National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan.ORCID 0000-0002-0686-4729
Ming-Tsang WuResearch Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.ORCID 0000-0001-7307-7816
Kaohsiung Medical University · TWE-Da Hospital · TWNational Health Research Institutes · TWNational Yang Ming Chiao Tung University · TWTzu Chi University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBecause there are no published biochemical reference intervals (RI) for pregnant Taiwanese women, we used an established islandwide birth cohort, the Taiwan Maternal and Infant Cohort Study, to establish RIs for important biochemical parameters in women during their 3rd trimester in Taiwan. Additionally, we compared the differences in these biochemical parameters between early third trimester (weeks 28 to 31) and late third trimester (weeks 37 to 40) of pregnant women as well as the differences in them between the third trimester and after delivery.

methodsBetween 2012 and 2015, we recruited a total of 2,136 pregnant women from nine hospitals located in northern (n = 3), central (n = 3), southern (n = 2), and eastern Taiwan (n = 1) to receive regular prenatal health examinations during their third trimester (weeks 28 to 40). After exclusion, samples obtained from 993 eligible pregnant women were analyzed.

resultsThere were increases in both lower and upper normal limits for blood neutrophil, thyroid profile (triiodothyronine (T3) and thyroxine (T4)), testosterone, estradiol, and progesterone and decreases for RBC, hemoglobin (Hb), alanine aminotransferase (ALT) and creatinine (Cr) during their third trimesters. Women in their late third trimester (n = 378) had higher median RBC, Hb, aspartate aminotransferase (AST), Cr, thyroid-stimulating hormone (TSH), testosterone, estradiol, and progesterone and lower median platelet and insulin, compared with those in their early third trimester (n = 490). Twenty-three of the women had both third trimester and post-pregnancy data. After delivery, the women had lower median AST, ALT, insulin, T3, T4, testosterone, estradiol, and progesterone and higher median Cr, free T4, FSH, and luteinizing hormone (LH), compared to their third trimesters.

conclusionsGestation-related changes in important biochemical parameters should be considered when evaluating clinical laboratory values in pregnant women.

Indexed as

AdultAlanine TransaminaseAspartate AminotransferasesBody Mass IndexClinical Chemistry TestsCohort StudiesEstradiolFemaleHematologic TestsHumansLeukocyte CountNeutrophilsPostpartum PeriodPregnancyPregnancy Trimester, FirstPregnancy Trimester, ThirdAlanine TransaminaseAspartate AminotransferasesEstradiolThyroid Hormones

Identifiers

PMID33315949
PMCPMC7735596
OpenAlexW3110825259

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.