ArticlePLoS computational biology2020
A Bayesian computational model reveals a failure to adapt interoceptive precision estimates across depression, anxiety, eating, and substance use disorders.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06332963 (Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa), which is not on this map. Cited by 94 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa
Who cites it
94 citing papers in PubMed.
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- Computational mechanisms of learning and forgetting differentiate affective and substance use disorders.Molecular psychiatry · 2026Article
- Writing Increases Precision-Weighted Inference of Conceptual Organization: A Bayesian-Brain Active-Inference Model of the Writing-over-Speaking Advantage in Analytic Thinking.Brain sciences · 2026Article
- Errors or Adaptations? A Critical Review of Predictive Processing in Psychiatry.Behavioral sciences (Basel, Switzerland) · 2026Review
- Exposure to false cardiac feedback alters pain perception and anticipatory cardiac frequency.eLife · 2026Article
- Evidence for Cardiac Phase-Linked Perception of Heartbeats.Psychophysiology · 2026Article
- Widely used bandit tasks elicit diverging belief updating phenotypes in healthy adults.Research square · 2026Article
- A Conceptual Framework for Understanding Patient Expectations in Individualised Anaesthesia and Analgesia: A Narrative Review and Future Directions.Journal of personalized medicine · 2026Review
- Breath, Belief, and Brain: A Tripartite Map of Respiratory Interoception.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Interoceptive ability is uncorrelated across respiratory and cardiac axes in a large scale psychophysical study.Communications psychology · 2026Article
- Eating disorder symptoms and corresponding evidence-based treatments: a narrative review.Journal of eating disorders · 2026Review
- Intraindividual Variability Matters for the Correspondence Between Subjective Arousal, Valence, and Physiological Responses.Psychophysiology · 2026Article
- The phantastic organ: predictive processing in the brain.Frontiers in psychology · 2026Review
- From symptom-based heterogeneity to mechanism-based profiling in youth ADHD: the promise of computational psychiatry.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Attenuated heartbeat-evoked potentials in functional neurological disorder.Brain communications · 2026Article
- Attenuated learning rates for negative outcomes in substance use disorders: A replication and extension of prior longitudinal computational modeling results.Drug and alcohol dependence · 2026Article
- Assessment of gut-brain interactions: reframing DGBI symptoms from visceral hypersensitivity to computational interoceptive overfitting.Frontiers in physiology · 2026Article
- Decision-Making in Repeated Games: Insights from Active Inference.Behavioral sciences (Basel, Switzerland) · 2025Review
34 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Recent neurocomputational theories have hypothesized that abnormalities in prior beliefs and/or the precision-weighting of afferent interoceptive signals may facilitate the transdiagnostic emergence of psychopathology. Specifically, it has been suggested that, in certain psychiatric disorders, interoceptive processing mechanisms either over-weight prior beliefs or under-weight signals from the viscera (or both), leading to a failure to accurately update beliefs about the body. However, this has not been directly tested empirically. To evaluate the potential roles of prior beliefs and interoceptive precision in this context, we fit a Bayesian computational model to behavior in a transdiagnostic patient sample during an interoceptive awareness (heartbeat tapping) task. Modelling revealed that, during an interoceptive perturbation condition (inspiratory breath-holding during heartbeat tapping), healthy individuals (N = 52) assigned greater precision to ascending cardiac signals than individuals with symptoms of anxiety (N = 15), depression (N = 69), co-morbid depression/anxiety (N = 153), substance use disorders (N = 131), and eating disorders (N = 14)-who failed to increase their precision estimates from resting levels. In contrast, we did not find strong evidence for differences in prior beliefs. These results provide the first empirical computational modeling evidence of a selective dysfunction in adaptive interoceptive processing in psychiatric conditions, and lay the groundwork for future studies examining how reduced interoceptive precision influences visceral regulation and interoceptively-guided decision-making.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.