Evidence map›Paper›PMID 33315276›Full record

SynthesisHippocampus2021

Exercise interventions preserve hippocampal volume: A meta-analysis.

Kristine A Wilckens, Chelsea M Stillman, Aashna M Waiwood, Chaeryon Kang, Regina L Leckie, Jamie C Peven, Jill E Foust, Scott H Fraundorf, Kirk I Erickson

Open access · greenAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Hippocampus, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 8 pooled it
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 8 syntheses or guidelines pooled it, 110 citations in OpenAlex.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kristine A WilckensDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8273-8476
Chelsea M StillmanDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Aashna M WaiwoodDepartment of Psychology, University of South Florida, Tampa, Florida, USA.
Chaeryon KangDepartment of Biostatistics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Regina L LeckieDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jamie C PevenDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jill E FoustHealth Sciences Library System, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Scott H FraundorfDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kirk I EricksonDepartment of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
University of Pittsburgh · USUniversity of South Florida · US

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Caterina Rosano · 2004 to 2026
$28.6M
Sunshine Education research CenterT42OH008438 · OH · UNIVERSITY OF SOUTH FLORIDA · PI MARSHALL, JENNIFER · 2005 to 2025
$28.2M
Investigating Gains in Neurocognition in an Intervention Trial of Exercise SupplementR01AG053952 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BURNS, JEFFREY MURRAY, ERICKSON, KIRK I · 2016 to 2020
$27.5M
CARDIOVASCULAR BEHAVIORAL MEDICINE RESEARCH TRAININGT32HL007560 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Peter J Gianaros, REBECCA C THURSTON · 1985 to 2026
$11.3M
CLINICAL RESEARCH TRAINING IN LATE-LIFE MOOD DISORDERST32MH019986 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Carmen Andreescu · 1997 to 2026
$6.9M
Rhythm Experience and Africana Culture Trial (REACT)R01AG060741 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2018 to 2024
$4.0M
Slow-wave sleep enhancement in those at risk for Alzheimer's disease: Links with memory, excitotoxicity, and plasma A-betaR01AG068001 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILCKENS, KRISTINE ANN · 2021 to 2025
$3.4M
Influence of Physical Activity and Weight Loss on Brain PlasticityR01DK095172 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ERICKSON, KIRK I · 2012 to 2016
$2.1M
Slow-wave sleep and executive network function in older adultsK01AG049879 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WILCKENS, KRISTINE ANN · 2016 to 2020
$713k
NHLBI NIH HHS T32 HL007560NIA NIH HHS K01 AG049879NIA NIH HHS P30 AG024827NIA NIH HHS R01 AG053952NIA NIH HHS R01 AG060741NIA NIH HHS R01 AG068001NIDDK NIH HHS R01 DK095172NIMH NIH HHS L30 MH104747NIMH NIH HHS T32 MH019986NIOSH CDC HHS T42 OH008438
6 · The paper itself

Abstract

Hippocampal volume is a marker of brain health and is reduced with aging and neurological disease. Exercise may be effective at increasing and preserving hippocampal volume, potentially serving as a treatment for conditions associated with hippocampal atrophy (e.g., dementia). This meta-analysis aimed to identify whether exercise training has a positive effect on hippocampal volume and how population characteristics and exercise parameters moderate this effect. Studies met the following criteria: (a) controlled trials; (b) interventions of physical exercise; (c) included at least one time-point of hippocampal volume data before the intervention and one after; (d) assessed hippocampal volume using either manual or automated segmentation algorithms. Animal studies, voxel-based morphometry analyses, and multi-modal interventions (e.g., cognitive training or meditation) were excluded. The primary analysis in n = 23 interventions from 22 published studies revealed a significant positive effect of exercise on total hippocampal volume. The overall effect was significant in older samples (65 years of age or older) and in interventions that lasted over 24 weeks and had less than 150 min per week of exercise. These findings suggest that moderate amounts of exercise for interventions greater than 6 months have a positive effect on hippocampal volume including in older populations vulnerable to hippocampal atrophy.

Indexed as

Cognition DisordersHippocampusAgedAtrophyExerciseExercise TherapyHumansInfantagingexercisehippocampusmagnetic resonance imagingphysical activity

Identifiers

PMID33315276
PMCPMC11497212
OpenAlexW3112460701

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.