ArticleAmerican journal of industrial medicine2021
Cardiovascular disease in the World Trade Center Health Program General Responder Cohort.
Article in American journal of industrial medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 20 citations in OpenAlex.
- Prolonged brain cytokine elevation and microgliosis following exposure to World Trade Center dust particulate matter in male spontaneously hypertensive rats.Journal of immunotoxicology · 2026Article
- Prevention of atherosclerotic coronary artery disease in tactical athletes.American journal of preventive cardiology · 2026Review
- Long-term Exposure to PMmedRxiv : the preprint server for health sciences · 2026Article
- Overcoming social determinants: World trade center health program monitoring use among the general responders.Preventive medicine reports · 2026Article
- Worsened longitudinal visit-to-visit-FEVLung · 2026Article
- Effect of World Trade Center Health Program on mortality among 9/11 responders.Annals of epidemiology · 2026Article
- The association between long-term exposure to PM2.5 constituents and diabetes incidence and blood glucose levels among World Trade Center Health Program general responders.American journal of epidemiology · 2026Article
- Dust exposure and lung function among firefighters involved in rescue and relief operations after the Great East Japan Earthquake.Journal of occupational health · 2026Article
- Association of COVID-19 Severity with Comorbidities: Results from the World Trade Center Health Registry.International journal of environmental research and public health · 2025Article
- Deciphering expression and variants in cardiovascular disease genes among heart failure population for precision medicine.ESC heart failure · 2024Article
- The Association of Air Pollution Exposure With Glucose and Lipid Levels: The Role of an Extreme Air Pollution Event Alongside 2 Decades of Moderate Exposure.American journal of epidemiology · 2024Article
- Deciphering genomic signatures associating human dental oral craniofacial diseases with cardiovascular diseases using machine learning approaches.Clinical oral investigations · 2024Article
- World Trade Center Exposure, DNA Methylation Changes, and Cancer: A Review of Current Evidence.Epigenomes · 2023Review
- A 15-year follow-up study of mortality in a pooled cohort of World Trade Center rescue and recovery workers.Environmental research · 2023Article
- Fine particulate matter and incident coronary heart disease events up to 10 years of follow-up among Deepwater Horizon oil spill workers.Environmental research · 2023Article
- Exposure to World Trade Center Dust Exacerbates Cognitive Impairment and Evokes a Central and Peripheral Pro-Inflammatory Transcriptional Profile in an Animal Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
- Autoimmune conditions in the World Trade Center general responder cohort: A nested case-control and standardized incidence ratio analysis.American journal of industrial medicine · 2022Article
- Health effects following exposure to dust from the World Trade Center disaster: An update.Life sciences · 2022Review
- Longitudinal Impact of WTC Dust Inhalation on Rat Cardiac Tissue Transcriptomic Profiles.International journal of environmental research and public health · 2022Article
- The World Trade Center Health Program: Twenty years of health effects research.American journal of industrial medicine · 2021Article
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundOver 90,000 rescue and recovery responders to the September 2001 World Trade Center (WTC) attacks were exposed to toxic materials that can impair cardiac function and increase cardiovascular disease (CVD) risk. We examined WTC-related exposures association with annual and cumulative CVD incidence and risk over 17 years in the WTC Health Program (HP) General Responder Cohort (GRC).
methodsPost 9/11 first occurrence of CVD was assessed in 37,725 responders from self-reported physician diagnosis of, or current treatment for, coronary artery disease, myocardial infarction, stroke and/or congestive heart failure from WTCHP GRC monitoring visits. Kaplan-Meier estimates of CVD incidence used the generalized Wilcoxon test statistic to account for censored data. Cox proportional hazards regression analyses estimated the CVD hazard ratio associated with 9/11/2001 arrival in responders with and without dust cloud exposure, compared with arrival on or after 9/12/2001. Additional analyses adjusted for comorbidities.
resultsTo date, 6.3% reported new CVD. In covariate-adjusted analyses, men's CVD 9/11/2001 arrival risks were 1.40 (95% confidence interval [CI] = 1.26, 1.56) and 1.43 (95% CI = 1.29, 1.58) and women's were 2.16 (95% CI = 1.49, 3.11) and 1.59 (95% CI = 1.11, 2.27) with and without dust cloud exposure, respectively. Protective service employment on 9/11 had higher CVD risk.
conclusionsWTCHP GRC members with 9/11/2001 exposures had substantially higher CVD risk than those initiating work afterward, consistent with observations among WTC-exposed New York City firefighters. Women's risk was greater than that of men's. GRC-elevated CVD risk may also be occurring at a younger age than in the general population.
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