Evidence map›Paper›PMID 33315181›Full record

Trial reportInfection2021

Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore.

Chaminda J Seneviratne, Preethi Balan, Kwan Ki Karrie Ko, Nadeeka S Udawatte, Deborah Lai, Dorothy Hui Lin Ng, Indumathi Venkatachalam, Kheng Sit Lim, Moi Lin Ling, Lynette Oon and 2 more

Open access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 10 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 10 syntheses or guidelines pooled it, 196 citations in OpenAlex.

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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Chaminda J Seneviratne *Singapore Oral Microbiomics Initiative, National Dental Research Institute Singapore (NDRIS), National Dental Centre Singapore, SingHealth, Singapore, Singapore. jaya.seneviratne@ndcs.com.sg.
Preethi Balan *Singapore Oral Microbiomics Initiative, National Dental Research Institute Singapore (NDRIS), National Dental Centre Singapore, SingHealth, Singapore, Singapore.
Kwan Ki Karrie Ko *Department of Microbiology, Singapore General Hospital, SingHealth, Singapore, Singapore.
Nadeeka S UdawatteSingapore Oral Microbiomics Initiative, National Dental Research Institute Singapore (NDRIS), National Dental Centre Singapore, SingHealth, Singapore, Singapore.
Deborah LaiDepartment of Microbiology, Singapore General Hospital, SingHealth, Singapore, Singapore.
Dorothy Hui Lin NgDepartment of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
Indumathi VenkatachalamDepartment of Infectious Diseases, Singapore General Hospital, Singapore, Singapore.
Kheng Sit LimDepartment of Urology, Singapore General Hospital, Singapore, Singapore.
Moi Lin LingDepartment of Infection Prevention and Epidemiology, Singapore General Hospital, Singapore, Singapore.
Lynette OonDepartment of Microbiology, Singapore General Hospital, SingHealth, Singapore, Singapore.
Bee Tin GohSingapore Oral Microbiomics Initiative, National Dental Research Institute Singapore (NDRIS), National Dental Centre Singapore, SingHealth, Singapore, Singapore.
Xiang Ying Jean Sim *Department of Infectious Diseases, Singapore General Hospital, Singapore, Singapore. jean.sim.x.y@singhealth.com.sg.
Singapore General Hospital · SGSingHealth · SGDuke-NUS Medical School · SGNational Dental Centre of Singapore · SG

Funding

NDCS/NDRIS (11/FY2019/G1/02-A44)NDCS/NDRIS (133/20)
6 · The paper itself

Abstract

purposeOne of the key approaches to minimize the risk of COVID-19 transmission would be to reduce the titres of SARS-CoV-2 in the saliva of infected COVID-19 patients. This is particularly important in high-risk procedures like dental treatment. The present randomized control trial evaluated the efficacy of three commercial mouth-rinse viz. povidone-iodine (PI), chlorhexidine gluconate (CHX) and cetylpyridinium chloride (CPC), in reducing the salivary SARS-CoV-2 viral load in COVID-19 patients compared with water.

methodsA total of 36 SARS-CoV-2-positive patients were recruited, of which 16 patients were randomly assigned to four groups-PI group (n = 4), CHX group (n = 6), CPC group (n = 4) and water as control group (n = 2). Saliva samples were collected from all patients at baseline and at 5 min, 3 h and 6 h post-application of mouth-rinses/water. The samples were subjected to SARS-CoV-2 RT-PCR analysis.

resultsComparison of salivary Ct values of patients within each group of PI, CHX, CPC and water at 5 min, 3 h and 6 h time points did not show any significant differences. However, when the Ct value fold change of each of the mouth-rinse group patients were compared with the fold change of water group patients at the respective time points, a significant increase was observed in the CPC group patients at 5 min and 6 h and in the PI group patients at 6 h.

conclusionThe effect of decreasing salivary load with CPC and PI mouth-rinsing was observed to be sustained at 6 h time point. Within the limitation of the current study, as number of the samples analyzed, the use of CPC and PI formulated that commercial mouth-rinses may be useful as a pre-procedural rinse to help reduce the transmission of COVID-19. ISRCTN (ISRCTN95933274), 09/09/20, retrospectively registered.

Indexed as

COVID-19 Drug TreatmentAdultAnti-Infective Agents, LocalCetylpyridiniumChlorhexidineCOVID-19FemaleHumansMaleMiddle AgedMouthwashesPovidone-IodineSalivaSARS-CoV-2SingaporeTreatment OutcomeAnti-Infective Agents, LocalCetylpyridiniumChlorhexidinechlorhexidine gluconateMouthwashesPovidone-IodineAntisepticsClinical trialCOVID-19Mouth-rinsesSalivaSARS-CoV-2

Identifiers

PMID33315181
PMCPMC7734110
OpenAlexW3112047315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.