Evidence map›Paper›PMID 33315154›Full record

ArticleSports medicine - open2020

Androgen deprivation in prostate cancer: benefits of home-based resistance training.

Teresa Lam, Birinder Cheema, Amy Hayden, Stephen R Lord, Howard Gurney, Shivanjini Gounden, Navneeta Reddy, Haleh Shahidipour, Scott Read, Glenn Stone and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sports medicine - open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 7 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 7 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Teresa LamSchool of Medicine, Western Sydney University, Penrith, NSW, Australia. Teresa.Lam@health.nsw.gov.au.ORCID http://orcid.org/0000-0003-4812-9113
Birinder CheemaSchool of Science and Health, Western Sydney University, Penrith, NSW, Australia.
Amy HaydenDepartment of Radiation Oncology, Blacktown Hospital, Blacktown, NSW, Australia.
Stephen R LordNeuRA, University of New South Wales, Sydney, NSW, Australia.
Howard GurneyCrown Princess Mary Cancer Centre, Westmead Hospital, Sydney, NSW, Australia.
Shivanjini GoundenSchool of Science and Health, Western Sydney University, Penrith, NSW, Australia.
Navneeta ReddySchool of Medicine, Western Sydney University, Penrith, NSW, Australia.
Haleh ShahidipourSchool of Medicine, Western Sydney University, Penrith, NSW, Australia.
Scott ReadSchool of Medicine, Western Sydney University, Penrith, NSW, Australia.
Glenn StoneSchool of Computing, Engineering and Mathematics, Western Sydney University, Penrith, NSW, Australia.
Mark McLeanSchool of Medicine, Western Sydney University, Penrith, NSW, Australia.
Vita BirznieceSchool of Medicine, Western Sydney University, Penrith, NSW, Australia.
Blacktown & Mount Druitt Hospital · AUWestern Sydney University · AUTranslational Research Institute · AUUNSW Sydney · AUWaterNSW · AUWestmead Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAndrogen deprivation therapy (ADT) has detrimental effects on body composition, metabolic health, physical functioning, bone mineral density (BMD) and health-related quality of life (HRQOL) in men with prostate cancer. We investigated whether a 12-month home-based progressive resistance training (PRT) programme, instituted at the start of ADT, could prevent these adverse effects.

methodsTwenty-five patients scheduled to receive at least 12 months of ADT were randomly assigned to either usual care (UC) (n = 12) or PRT (n = 13) starting immediately after their first ADT injection. Body composition, body cell mass (BCM; a functional component of lean body mass), BMD, physical function, insulin sensitivity and HRQOL were measured at 6 weeks and 6 and 12 months. Data were analysed by a linear mixed model.

resultsADT had a negative impact on body composition, BMD, physical function, glucose metabolism and HRQOL. At 12 months, the PRT group had greater reductions in BCM by - 1.9 ± 0.8 % (p = 0.02) and higher gains in fat mass by 3.1 ± 1.0 % (p = 0.002), compared to the UC group. HRQOL domains were maintained or improved in the PRT versus UC group at 6 weeks (general health, p = 0.04), 6 months (vitality, p = 0.02; social functioning, p = 0.03) and 12 months (mental health, p = 0.01; vitality, p = 0.02). A significant increase in the Matsuda Index in the PRT versus UC group was noted at 6 weeks (p = 0.009) but this difference was not maintained at subsequent timepoints. Between-group differences favouring the PRT group were also noted for physical activity levels (step count) (p = 0.02). No differences in measures of BMD or physical function were detected at any time point.

conclusionA home-based PRT programme instituted at the start of ADT may counteract detrimental changes in body composition, improve physical activity and mental health over 12 months.

trial registrationAustralian and New Zealand Clinical Trials Registry, ACTRN12616001311448.

Indexed as

Adverse effectsAndrogen deprivation therapyProgressive resistance trainingProstate cancer

Identifiers

PMID33315154
PMCPMC7736381
OpenAlexW3111718628

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.