ArticleSocial cognitive and affective neuroscience2021
Hippocampal subfield alterations in pediatric patients with post-traumatic stress disorder.
Article in Social cognitive and affective neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Neural correlates of resilience to trauma during adolescence: A multi-modal study.JCPP advances · 2026Article
- Predicting Traumatic Brain Injury Post-Trauma Using Temporal Attention on Sleep-Wake Data.IEEE transactions on bio-medical engineering · 2026Article
- Structural Brain Correlates of Multidomain Resilience Among Youth Exposed to Neighborhood Disadvantage.Biological psychiatry global open science · 2025Article
- The effects of adverse life events on brain development in the ABCD study®: a propensity-weighted analysis.Molecular psychiatry · 2025Article
- Peripheral DNA Methylation of Cortisol- and Serotonin-Related Genes Predicts Hippocampal Volume in a Pediatric Population.Biological psychiatry global open science · 2025Article
- Temporal-Posterior Alpha Power in Resting-State Electroencephalography as a Potential Marker of Complex Childhood Trauma in Institutionalized Adolescents.Brain sciences · 2024Article
- The application of machine learning techniques in posttraumatic stress disorder: a systematic review and meta-analysis.NPJ digital medicine · 2024Review
- Characterizing White Matter Changes along Fibers in Treatment-Naive Pediatric Posttraumatic Stress Disorder.Depression and anxiety · 2023Article
- Neural correlates of disaster-related prenatal maternal stress in young adults from Project Ice Storm: Focus on amygdala, hippocampus, and prefrontal cortex.Frontiers in human neuroscience · 2023Article
- Hippocampal Resting-State Functional Connectivity Forecasts Individual Posttraumatic Stress Disorder Symptoms: A Data-Driven Approach.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus, a key structure with distinct subfield functions, is strongly implicated in the pathophysiology of post-traumatic stress disorder (PTSD); however, few studies of hippocampus subfields in PTSD have focused on pediatric patients. We therefore investigated the hippocampal subfield volume using an automated segmentation method and explored the subfield-centered functional connectivity aberrations related to the anatomical changes, in a homogenous population of traumatized children with and without PTSD. To investigate the potential diagnostic value in individual patients, we used a machine learning approach to identify features with significant discriminative power for diagnosis of PTSD using random forest classifiers. Compared to controls, we found significant mean volume reductions of 8.4% and 9.7% in the right presubiculum and hippocampal tail in patients, respectively. These two subfields' volumes were the most significant contributors to group discrimination, with a mean classification accuracy of 69% and a specificity of 81%. These anatomical alterations, along with the altered functional connectivity between (pre)subiculum and inferior frontal gyrus, may underlie deficits in fear circuitry leading to dysfunction of fear extinction and episodic memory, causally important in post-traumatic symptoms such as hypervigilance and re-experience. For the first time, we suggest that hippocampal subfield volumes might be useful in discriminating traumatized children with and without PTSD.
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