Evidence map›Paper›PMID 33315010›Full record

ArticleeLife2020

The connectome of the adult Drosophila mushroom body provides insights into function.

Feng Li, Jack W Lindsey, Elizabeth C Marin, Nils Otto, Marisa Dreher, Georgia Dempsey, Ildiko Stark, Alexander S Bates, Markus William Pleijzier, Philipp Schlegel and 15 more

Abstract readVideo-Audio Media
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 208 papers.

0numbers the graph read from it
0cells of the map it votes in
208citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

208 citing papers in PubMed.

  1. Article
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  11. Review
  12. Article
  13. The evolution of lepidopteran brain morphology.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Article
  14. The diversity of lepidopteran spatial orientation strategies - neuronal mechanisms and emerging challenges in a changing world.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  15. Article
  16. Article
  17. Article
  18. Modular presynaptic assemblages scale to postsynaptic partner number.bioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. Redox regulation of memory formation by Rrp1 inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article

148 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Feng LiJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-6658-9175
Jack W LindseyDepartment of Neuroscience, Columbia University, Zuckerman Institute, New York, United States.ORCID 0000-0003-0930-7327
Elizabeth C MarinDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-6333-0072
Nils OttoDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9713-4088
Marisa DreherJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-0041-9229
Georgia DempseyDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-1854-8336
Ildiko StarkDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.
Alexander S BatesNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID 0000-0002-1195-0445
Markus William PleijzierNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.ORCID 0000-0002-7297-4547
Philipp SchlegelDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-5633-1314
Aljoscha NernJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-3822-489X
Shin-Ya TakemuraJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-2400-6426
Nils EcksteinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
Tansy YangJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-1131-0410
Audrey FrancisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0003-1974-7174
Amalia BraunDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.
Ruchi ParekhJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-8060-2807
Marta CostaDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-5948-3092
Louis K SchefferJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-3289-6564
Yoshinori AsoJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0002-2939-1688
Gregory Sxe JefferisDrosophila Connectomics Group, Department of Zoology, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-0587-9355
Larry F AbbottDepartment of Neuroscience, Columbia University, Zuckerman Institute, New York, United States.
Ashok Litwin-KumarDepartment of Neuroscience, Columbia University, Zuckerman Institute, New York, United States.ORCID 0000-0003-2422-6576
Scott WaddellCentre for Neural Circuits & Behaviour, University of Oxford, Oxford, United Kingdom.ORCID 0000-0003-4503-6229
Gerald M RubinJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.ORCID 0000-0001-8762-8703

Funding

ADVANCED GRADUATE TRAINING PROGRAM IN THEORETICAL NEUROSCIENCET32NS064929 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Laurence F. Abbott, Roudabeh Behnia · 2009 to 2026
$2.9M
Relating structure and function in synapse-level wiring diagramsR01EB029858 · NIBIB · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LITWIN-KUMAR, ASHOK · 2020 to 2020
$1.2M
Burroughs Wellcome Fund 1017109Department of Energy DE-SC0020347Howard Hughes Medical InstituteHoward Hughes Medical Institute internal fundingMedical Research Council MC-U105188491Medical Research Council MC_U105188491National Science Foundation NeuroNex DBI-1707398NIBIB NIH HHS R01 EB029858NIH HHS R01EB029858NINDS NIH HHS T32 NS064929Simons Foundation SCGBWellcome Trust 200846/Z/16/ZWellcome Trust 203261/Z/16/Z
6 · The paper itself

Abstract

Making inferences about the computations performed by neuronal circuits from synapse-level connectivity maps is an emerging opportunity in neuroscience. The mushroom body (MB) is well positioned for developing and testing such an approach due to its conserved neuronal architecture, recently completed dense connectome, and extensive prior experimental studies of its roles in learning, memory, and activity regulation. Here, we identify new components of the MB circuit in

Indexed as

ConnectomeAnimalsBrain MappingDrosophila melanogasterMushroom BodiesbehaviorD. melanogasterdopaminelearningmemoryneuronal circuitsneuroscience

Identifiers

PMID33315010
PMCPMC7909955

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.