Evidence map›Paper›PMID 33314922›Full record

ArticleACS chemical biology2021

Exploring the Ligand Preferences of the PHD1 Domain of Histone Demethylase KDM5A Reveals Tolerance for Modifications of the Q5 Residue of Histone 3.

Sarah E Anderson, James E Longbotham, Patrick T O'Kane, Fatima S Ugur, Danica Galonić Fujimori, Milan Mrksich

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sarah E AndersonDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
James E LongbothamDepartment of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States.
Patrick T O'KaneDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.
Fatima S UgurChemistry and Chemical Biology Graduate Program, University of California San Francisco, San Francisco, California 94158, United States.
Danica Galonić FujimoriDepartment of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, United States.ORCID 0000-0002-4066-9417
Milan MrksichDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, United States.ORCID 0000-0002-4964-796X
Northwestern University · USUniversity of California, San Francisco · US

Funding

Allosteric Regulation in the KDM5 Family of Histone DemethylasesR01GM114044 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FUJIMORI, DANICA GALONIC · 2015 to 2018
$1.3M
NIGMS NIH HHS R01 GM114044
6 · The paper itself

Abstract

Understanding the ligand preferences of epigenetic reader domains enables identification of modification states of chromatin with which these domains associate and can yield insight into recruitment and catalysis of chromatin-acting complexes. However, thorough exploration of the ligand preferences of reader domains is hindered by the limitations of traditional protein-ligand binding assays. Here, we evaluate the binding preferences of the PHD1 domain of histone demethylase KDM5A using the protein interaction by SAMDI (PI-SAMDI) assay, which measures protein-ligand binding in a high-throughput and sensitive manner

Indexed as

Fluorescence PolarizationHistonesHumansHypoxia-Inducible Factor-Proline DioxygenasesLigandsRetinoblastoma-Binding Protein 2EGLN2 protein, humanHistonesHypoxia-Inducible Factor-Proline DioxygenasesKDM5A protein, humanLigandsRetinoblastoma-Binding Protein 2

Identifiers

PMID33314922
PMCPMC8168426
OpenAlexW3110671268

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.