Evidence map›Paper›PMID 33314806›Full record

ArticleInvestigative and clinical urology2021

Immune responses against autologous tumor and human papilloma virus in lymph nodes from patients with penile cancer.

Lu Zhang, A Ali Zirakzadeh, Jesper Rosvall, Mats Hedlund, Ping Sheng Hu, Katrine Riklund, Amir Sherif, Ola Winqvist

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative and clinical urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Lu ZhangDepartment of Medicine, Immunology and Allergy Unit, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7876-480X
A Ali ZirakzadehDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.ORCID 0000-0002-1568-1430
Jesper RosvallDepartment of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8940-6645
Mats HedlundDepartment of Urology, UroClinic® prostatacenter, Sophiahemmet, Stockholm, Sweden.ORCID 0000-0002-4059-4515
Ping Sheng HuCancer Biotherapy Center, Affiliated Hospital of Guizhou Medical University, Guiyang, China.ORCID 0000-0003-4027-3380
Katrine RiklundDepartment of Radiation Sciences, Umeå University, Umeå, Sweden.ORCID 0000-0001-5227-8117
Amir SherifDepartment of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden. amir.sherif@urologi.umu.se.ORCID 0000-0002-3675-3050
Ola WinqvistDepartment of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-0842-4441
Umeå University · SEKarolinska Institutet · SEGuiyang Medical University · CNKarolinska University Hospital · SESophiahemmet University College · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNearly half of penile cancers are related to human papillomavirus (HPV) infection. Investigations of tumor- and HPV-specific T cell reactivity in regional lymph nodes (LNs) from patients with penile cancer are warranted. MATERIALS AND

methodsIn this study, single-cell suspensions from LNs and peripheral blood from 11 patients with penile cancer were stained with antibodies for lymphocyte markers and analyzed by fluorescence-activated cell sorting (FACS). DNA was extracted from the tumor tissue and HPV status was investigated by PCR.

resultsT-cell reactivity against autologous tumor-extract and against the HPV-vaccine Gardasil® was tested by flow-cytometric assay of specific cell-mediated immune response in activated whole blood (FASCIA). CD4

conclusionsLN-derived T cells from patients with penile cancer recognize tumor antigen(s) and in HPV-positive cases, there is a response against L1 (late) HPV proteins, being constituents of the Gardasil vaccine.

Indexed as

AgedAged, 80 and overAntigens, NeoplasmCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesHuman Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18HumansImmunophenotypingLymph NodesLymphocyte ActivationMaleMiddle AgedPapillomaviridaePenile NeoplasmsViral ProteinsAntigens, NeoplasmHuman Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18Viral ProteinsAdoptive immunityLymph node excisionPapillomaviridaePenile neoplasmsT-lymphocytes

Identifiers

PMID33314806
PMCPMC7801168
OpenAlexW3098387281

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.