ArticleESC heart failure2021
Association between base excess and mortality in patients with congestive heart failure.
Article in ESC heart failure, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Impact of base excess on mortality in patients with sepsis-associated acute kidney injury: insights from US Intensive Care Unit Cohort.International urology and nephrology · 2026Article
- Tendency to acidosis or alkalosis: Which one is associated with coronary artery disease?Journal of cardiovascular and thoracic research · 2025Article
- Prognostic value of lactate-to-hemoglobin ratio in nontraumatic critically ill patients presenting to the emergency department: a retrospective cohort study.BMC emergency medicine · 2025Observational
- The association between anion gap and prognosis in patients myocardial infarction with congestive heart failure: a retrospective analysis of the MIMIC-IV database.International journal of emergency medicine · 2025Article
- Association between base excess and mortality in critically ill patients with ischemic stroke: a retrospective cohort study.BMC neurology · 2024Article
- Development and validation of a novel combinatorial nomogram model to predict in-hospital deaths in heart failure patients.BMC cardiovascular disorders · 2024Article
- Association between lactate/albumin ratio and mortality in patients with heart failure after myocardial infarction.ESC heart failure · 2023Article
- Association between base excess and 28-day mortality in sepsis patients: A secondary analysis based on the MIMIC- IV database.Heliyon · 2023Article
- Applying an Improved Stacking Ensemble Model to Predict the Mortality of ICU Patients with Heart Failure.Journal of clinical medicine · 2022Article
- Base excess is associated with the risk of all-cause mortality in critically ill patients with acute myocardial infarction.Frontiers in cardiovascular medicine · 2022Article
- Association between base excess and mortality in patients with congestive heart failure.ESC heart failure · 2021Article
- Association Between Base Excess and Mortality Among Patients in ICU With Acute Kidney Injury.Frontiers in medicine · 2021Article
- Evaluation of factors affecting the success of non invasive mechanical ventilation in acute cardiogenic pulmonary edema in the emergency department.Turkish journal of emergency medicineArticle
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Authors and funding
7 authors.
Funding
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Abstract
aimsThe relationship between baseline base excess (BE) and survival outcomes in patients with congestive heart failure (CHF) is unclear. Therefore, we aimed to investigate this relationship based on the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database (v1.4). METHODS AND
resultsThis retrospective cohort study included 5956 adult patients with CHF from the MIMIC-III database from 2001 to 2012. Using the Cox proportional-hazard analysis and Kaplan-Meier plot, we evaluated the relationship between baseline BE and all-cause death at 1 year after admission to the intensive care unit. At the 1 year follow-up, 2104 participants (35.3%) had died. There was an association between BE and all-cause death (log-rank test P < 0.0001). In the Cox regression model adjusted for demographic and clinical variables, the risk of all-cause death in the first (BE ≤ -8), second (-8 < BE ≤ -3), fourth (2 < BE ≤ 7), and fifth (BE > 7) BE groups was significantly higher than that in the third BE group (-3 < BE ≤ 2) [hazard ratio (HR) 1.99, 95% confidence interval (CI) 1.62-2.43, HR 1.40, 95% CI 1.23-1.60, HR 1.46, 95% CI 1.26-1.69, and HR 1.68, 95% 1.33-2.12, respectively]. Similar results were observed when BE was modelled as a continuous variable using a Cox regression model with a restricted cubic spline.
conclusionsThis study demonstrated the existence of a U-shaped relationship between BE and survival outcome in patients with CHF. Both low and high BE increased the risk of all-cause mortality.
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