ArticleCancer medicine2021
Sentinel lymph node biopsy in early stage cervical cancer: A meta-analysis.
Article in Cancer medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The false-negative rate of sentinel lymph node biopsy and its related factors in early-stage cervical cancer: a systematic review and meta-analysis.Acta oncologica (Stockholm, Sweden) · 2026Pooled it
- Sentinel lymph node biopsy versus lymphadenectomy in early-stage cervical cancer: a meta-analysis of oncologic outcomes and surgical morbidity.Frontiers in oncology · 2026Pooled it
- Para-Aortic Lymph Node Metastasis Detected by Sentinel Lymph Node Biopsy in Cervical Cancer Initially Presumed to be Stage IA2: A Case Report.The journal of obstetrics and gynaecology research · 2026Article
- Virtual histology imaging of lymph nodesCancer biology & medicine · 2026Observational
- Translational Progress of Inorganic Nanotheranostic Platforms for Gynecologic Malignancies: A Narrative Review of Endometrial, Ovarian, and Cervical Cancer Focusing on Fertility Preservation, Biosafety, and Industrial Translation.International journal of nanomedicine · 2026Review
- Laparoscopy in the Surgical Management of Gynecological Cancer: A Comprehensive Update.Journal of clinical medicine · 2025Review
- Sentinel Lymph Node Dissection-Novelty, Trend, or a Paradigm Shift in Surgical Decision-Making for Early Cervical Cancer?Medicina (Kaunas, Lithuania) · 2025Review
- Sentinel Lymph Node Detection in Cervical Cancer: Challenges in Resource-Limited Settings with High Prevalence of Large Tumours.Journal of clinical medicine · 2025Article
- Article
- Oncologic Outcomes of Patients with Early-Stage Cervical Cancer after Minimally Invasive Radical Hysterectomy and Sentinel Lymph Node Biopsy.Journal of clinical medicine · 2024Article
- Consensus on surgical technique for sentinel lymph node dissection in cervical cancer.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2024Article
- A machine learning-based prediction model of pelvic lymph node metastasis in women with early-stage cervical cancer.Journal of gynecologic oncology · 2024Article
- Current applications of indocyanine green (ICG) in abdominal, gynecologic and urologic surgery: a meta-review and quality analysis with use of the AMSTAR 2 instrument.Surgical endoscopy · 2024Review
- Development of novel tracers for sentinel node identification in cervical cancer.Cancer science · 2023Article
- SUCCOR Nodes: May Sentinel Node Biopsy Determine the Need for Adjuvant Treatment?Annals of surgical oncology · 2023Article
- A preoperative prediction of lymph node metastasis in early cervical squamous cell cancer with hematologica - based model.Journal of Cancer · 2023Article
- [Carbon nanoparticle tracing of sentinel lymph nodes in diagnosis and treatment of cervical cancer and clinical value of lymph node ultrastaging detection].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- The lymphatic system and sentinel lymph nodes: conduit for cancer metastasis.Clinical & experimental metastasis · 2022Review
- Use of Nomogram to Predict the Risk of Lymph Node Metastasis among Patients with Cervical Adenocarcinoma.Journal of immunology research · 2022Article
- The 5-year overall survival of cervical cancer in stage IIIC-r was little different to stage I and II: a retrospective analysis from a single center.BMC cancer · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to determine the specific side detection rate of the sentinel lymph node biopsy and the accuracy in predicting lymph node metastasis in early stage cervical cancer.
methodsA systematic search of databases was performed from the inception of the databases to 27 June 2020. Studies of cervical cancer patients with FIGO stage FIGO ⅠA~ⅡB, evaluating the sentinel lymph node biopsy with blue dye, technetium 99, combined technique (blue dye with technetium 99) or indocyanine green with a reference standard of systematic pelvis lymph node dissection or clinical follow-up were included. Stata12.0 and Meta-Disc 1.4 were used for the meta-analysis.
resultsOf 2825 articles found, 21 studies (2234 women) were eventually included. Out of 21 studies, 20 met the detection rate evaluation criteria and six were included for sensitivity meta-analysis. Due to heterogeneity, it was inappropriate to pool all studies. The pooled specific side detection rates were 85% in tumors up to 2 cm, 67% in tumors over 2 cm, 75.2% for blue dye, 74.7% for technetium 99, 84% for combined technique, and 85.5% for indocyanine green. The sentinel lymph node biopsy had a pooled specific side sensitivity of 88%. Adverse effects of sentinel lymph node biopsy appear minimal for most patients and are mainly related to the injection of blue dye.
conclusionsSentinel lymph node biopsy using a tracer with a high detection rate and ultrastaging is highly accurate and reliable when limited to seriously selected patients, with satisfactory bilateral lymph node mapping and where enough cases for learning curve optimization exist. Indocyanine green sentinel lymph node mapping seems to be a superior sentinel lymph node mapping technique compared to other methods at present.
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