ArticleJournal of biophotonics2021
Characterizing thrombus with multiple red blood cell compositions by optical coherence tomography attenuation coefficient.
Article in Journal of biophotonics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 8 citations in OpenAlex.
- MicroCT Can Characterize Clots Retrieved With Mechanical Thrombectomy From Acute Ischemic Stroke Patients-A Preliminary Report.Frontiers in neurology · 2022Article
- Review
- Novel Human Acute Ischemic Stroke Blood Clot Analogs for In Vitro Thrombectomy Testing.AJNR. American journal of neuroradiology · 2021Article
- Optical coherence tomography for identification of malignant pulmonary nodules based on random forest machine learning algorithm.PloS one · 2021Article
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Authors and funding
9 authors at 2 institutions in 2 countries.
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Abstract
Embolectomy is one of the emergency procedures performed to remove emboli. Assessing the composition of human blood clots is an important diagnostic factor and could provide guidance for an appropriate treatment strategy for interventional physicians. Immunostaining has been used to identity compositions of clots as a gold-standard procedure, but it is time-consuming and cannot be performed in situ. Here, we proposed that the optical attenuation coefficient of optical coherence tomography (OCT) can be a reliable indicator as a new imaging modality to differentiate clot compositions. Fifteen human blood clots with multiple red blood cell (RBC) compositions from 21% to 95% were prepared using healthy human whole blood. A homogeneous gelatin phantom experiment and numerical simulation based on the Lambert-Beer's law were examined to verify the validity of the attenuation coefficient estimation. The results displayed that optical attenuation coefficients were strongly correlated with RBC compositions. We reported that attenuation coefficients could be a promising biomarker to guide the choice of an appropriate interventional device in a clinical setting and assist in characterizing blood clots.
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