Evidence map›Paper›PMID 33314545›Full record

Trial reportHuman brain mapping2021

Structural correlates underlying accelerated magnetic stimulation in Parkinson's disease.

Gong-Jun Ji, Tingting Liu, Ying Li, Pingping Liu, Jinmei Sun, Xingui Chen, Yanghua Tian, Xianwen Chen, Louisa Dahmani, Hesheng Liu and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07024875 (Precision Neuroimaging of Parkinson's Disease), which is not on this map. Cited by 35 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 7 pooled it
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07024875 recruitingnot on this mapstarted 2025, after this paper: background citation

Precision Neuroimaging of Parkinson's Disease

Typeobservational_patient_registrySponsorWashington University School of MedicineRan2025 to 2031Enrolled120ConditionsParkinsons Disease (PD)
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 7 syntheses or guidelines pooled it, 52 citations in OpenAlex.

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  4. Theta-burst stimulation as a therapeutic tool in neurological pathology: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Gong-Jun JiDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID 0000-0002-7073-5534
Tingting LiuDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Ying LiDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Pingping LiuDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Jinmei SunDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID 0000-0002-9295-2759
Xingui ChenDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Yanghua TianDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID 0000-0001-5038-0599
Xianwen ChenDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Louisa DahmaniDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Hesheng LiuDepartment of Neuroscience, Medical University of South Carolina, Charleston, South Carolina, USA.
Kai WangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID 0000-0002-6197-914X
Panpan HuDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Anhui Medical University · CNMedical University of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive neuromodulation technique with great potential in the treatment of Parkinson's disease (PD). This study aimed to investigate the clinical efficacy of accelerated rTMS and to understand the underlying neural mechanism. In a double-blinded way, a total of 42 patients with PD were randomized to receive real (n = 22) or sham (n = 20) continuous theta-burst stimulation (cTBS) on the left supplementary motor area (SMA) for 14 consecutive days. Patients treated with real cTBS, but not with sham cTBS, showed a significant improvement in Part III of the Unified PD Rating Scale (p < .0001). This improvement was observed as early as 1 week after the start of cTBS treatment, and maintained 8 weeks after the end of the treatment. These findings indicated that the treatment response was swift with a long-lasting effect. Imaging analyses showed that volume of the left globus pallidus (GP) increased after cTBS treatment. Furthermore, the volume change of GP was mildly correlated with symptom improvement and associated with the baseline fractional anisotropy of SMA-GP tracts. Together, these findings implicated that the accelerated cTBS could effectively alleviate motor symptoms of PD, maybe by modulating the motor circuitry involving the SMA-GP pathway.

Indexed as

Transcranial Magnetic StimulationDiffusion Tensor ImagingFemaleGlobus PallidusHumansMagnetic Resonance ImagingMaleMiddle AgedMotor CortexParkinson DiseaseTreatment Outcomecontinuous theta-burst stimulationfunctional connectivityParkinson's diseasetranscranial magnetic stimulation

Identifiers

PMID33314545
PMCPMC7978118
OpenAlexW3111981110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.