ArticleLiver international : official journal of the International Association for the Study of the Liver2021
Clinical characteristics and management of 1572 patients with pyogenic liver abscess: A 12-year retrospective study.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 2 of them syntheses that pooled it.
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63 citing papers in PubMed, 2 syntheses or guidelines pooled it, 90 citations in OpenAlex.
- Risk factors for invasiveFrontiers in cellular and infection microbiology · 2026Pooled it
- Pooled it
- Clinical efficacy of ulinastatin in the treatment of unliquefied pyogenic liver abscess complicated by septic shock: A randomized controlled trial.Immunity, inflammation and disease · 2023Trial
- Impact of the Prognostic Nutritional Index on Outcomes in Resectable Gallbladder Cancer.Annals of surgical oncology · 2026Article
- Article
- Association between prognostic nutritional index and clinical outcomes in patients with pyogenic liver abscess: a retrospective multicenter study.BMC infectious diseases · 2026Article
- When Clinical Improvement Does Not Reflect Radiological Response: A Culture-Negative Giant Pyogenic Liver Abscess.Healthcare (Basel, Switzerland) · 2026Article
- Complete Resolution of a Fusobacterium necrophorum Liver Abscess With Short-Course Antibiotics and Drainage.Cureus · 2026Article
- Integration of the National Early Warning Score 2 and the procalcitonin-to-albumin ratio for sepsis prediction in patients with pyogenic liver abscess: a retrospective cohort study.BMC infectious diseases · 2026Article
- Article
- Liver abscesses in Southern Europe: clinical and microbiological characterization of a retrospective cohort.BMC infectious diseases · 2026Observational
- The disguised liver abscess closely resembled diffuse hepatocellular carcinoma with portal vein tumor thrombus: a case description and literature analysis.Quantitative imaging in medicine and surgery · 2026Article
- Clinical characteristics and etiological analysis in liver abscess: a retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- Clinical Relevance and Utility of Serum APOC2 Levels in Patients with Type 2 Diabetes Mellitus: A Comparative Study on Subjects with and without Pyogenic Liver Abscess.Hepatic medicine : evidence and research · 2026Article
- Clinical, microbial and metabolic characteristics of gas-forming pyogenic liver abscess and its potential formation mechanism.Frontiers in cellular and infection microbiology · 2026Article
- Glycoconjugate Vaccines Against Nosocomial Klebsiella pneumoniae Infections.Advances in experimental medicine and biology · 2026Article
- Pyogenic liver abscess in the North Denmark Region - a population-based cohort study (2010-2022).European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Liver abscess and bacteremia caused byIDCases · 2026Article
- Clinical characteristics of pyogenic liver abscess patients with multiple organ dysfunction syndrome and development and validation of a predictive model.Frontiers in cellular and infection microbiology · 2026Article
- Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsPyogenic liver abscesses (PLA) are space-occupying lesions in the liver that produce high morbidity and mortality. The clinical characteristics and prognosis of abscesses is different depending on the bacterial culture results and require different strategies for management. The aim of this study was to investigate the clinical characteristics and prognostic factors of patients with PLA.
methodsClinical features, laboratory tests and etiology of PLA between 2006 to 2011 and 2012 to 2017 in a single hospital were retrospectively reviewed. The incidence and mortality of PLA caused by Escherichia coli and Klebsiella pneumoniae were compared and the risk factors for multiple organ dysfunction (MODS) and endophthalmitis were evaluated.
resultsAmong the 1,572 PLA patients, the proportion with PLA increased from 333 (21.2%) in 2006-2011 to 1,239 (78.8%) in 2012-2017 without any investigation and treatment procedure differences. K pneumoniae was the main isolate in analysed pus cultures (85.6%). The mortality rate of patients with K pneumoniae infection was lower in the latter period (6.7% vs 0.7%, P = .035). Multivariate analyses revealed that age, fever, MODS and length of hospital stay were factors affecting poor prognosis (death + unhealed/uncured) in PLA patients after treatment and that cardiovascular disease, pleural effusion and pulmonary infection were risk factors for MODS, while diabetes mellitus was the only risk factor for endophthalmitis. Most patients (95.5%) with PLA recovered after abscess drainage/puncture and antibiotic therapy.
conclusionsPleural effusion, fever, MODS and length of hospital stays were factors useful in predicting PLA outcomes.
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