Evidence map›Paper›PMID 33314422›Full record

ArticleNMR in biomedicine2021

Multi-sample measurement of hyperpolarized pyruvate-to-lactate flux in melanoma cells.

Hannah Lees, Micaela Millan, Fayyaz Ahamed, Roozbeh Eskandari, Kristin L Granlund, Sangmoo Jeong, Kayvan R Keshari

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NMR in biomedicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Increasing Infusion Times of Hyperpolarized [1-Magnetic resonance in medicine · 2026
    Article
  3. Article
  4. Assessment of the Feasibility of Hyperpolarized [1-Journal of magnetic resonance imaging : JMRI · 2024
    Article
  5. Article
  6. First in-human evaluation of [1-Magnetic resonance in medicine · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Hannah LeesDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-1684-3075
Micaela MillanDepartment of Chemistry, Hunter College of the City University of New York, New York, New York, USA.
Fayyaz AhamedDepartment of Bioengineering, University of California, Berkeley, California, USA.
Roozbeh EskandariDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Kristin L GranlundDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Sangmoo JeongDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Kayvan R KeshariDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0002-5181-8035
Memorial Sloan Kettering Cancer Center · USCity University of New York · USUniversity of California, Berkeley · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Reproducibility of Hyperpolarized Pyruvate Metabolic Imaging in Prostate CancerR01CA195476 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI HRICAK, HEDVIG, KESHARI, KAYVAN R · 2016 to 2018
$822k
uCoil NMR platform for robust and high-throughput analysis of in vitro metabolic flux on living cellsR21CA212958 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KESHARI, KAYVAN R · 2017 to 2019
$660k
GE Diamond DNP PolarizerS10OD016422 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI HRICAK, HEDVIG, KESHARI, KAYVAN R · 2014 to 2014
$600k
Hyperpolarized Micro-NMR for Quantitative Analysis of Metabolism in Leukemia Stem CellsK99CA226357 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI JEONG, SANGMOO · 2018 to 2019
$255k
NCI NIH HHS K99 CA226357NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA195476NCI NIH HHS R21 CA212958NIH HHS S10 OD016422
6 · The paper itself

Abstract

Hyperpolarized [1-

Indexed as

Metabolic Flux AnalysisCell Line, TumorHumansLactic AcidMelanomaMutationProto-Oncogene Proteins B-rafPyruvic AcidTreatment OutcomeLactic AcidProto-Oncogene Proteins B-rafPyruvic AcidBRAFcancerhyperpolarized 13C-MRSlactatemelanomapyruvate

Identifiers

PMID33314422
PMCPMC8288443
OpenAlexW3111495014

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.