Evidence map›Paper›PMID 33314360›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2021

Enantioselective Cleavage of Cyclobutanols Through Ir-Catalyzed C-C Bond Activation: Mechanistic and Synthetic Aspects.

Friederike Ratsch, Joss Pepe Strache, Waldemar Schlundt, Jörg-Martin Neudörfl, Andreas Adler, Sarwar Aziz, Bernd Goldfuss, Hans-Günther Schmalz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Friederike RatschDepartment of Chemistry, University of Cologne, Greinstraße 4, 50939, Köln, Germany.
Joss Pepe StracheDepartment of Chemistry, University of Cologne, Greinstraße 4, 50939, Köln, Germany.
Waldemar SchlundtDepartment of Chemistry, University of Cologne, Greinstraße 4, 50939, Köln, Germany.
Jörg-Martin NeudörflDepartment of Chemistry, University of Cologne, Greinstraße 4, 50939, Köln, Germany.
Andreas AdlerDepartment of Chemistry, University of Cologne, Greinstraße 4, 50939, Köln, Germany.
Sarwar AzizDepartment of Chemistry, University of Cologne, Greinstraße 4, 50939, Köln, Germany.
Bernd GoldfussDepartment of Chemistry, University of Cologne, Greinstraße 4, 50939, Köln, Germany.ORCID http://orcid.org/0000-0002-1814-8818
Hans-Günther SchmalzDepartment of Chemistry, University of Cologne, Greinstraße 4, 50939, Köln, Germany.ORCID http://orcid.org/0000-0003-0489-1827
University of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Ir-catalyzed conversion of prochiral tert-cyclobutanols to β-methyl-substituted ketones proceeds under comparably mild conditions in toluene (45-110 °C) and is particularly suited for the enantioselective desymmetrization of β-oxy-substituted substrates to give products with a quaternary chirality center with up to 95 % ee using DTBM-SegPhos as a chiral ligand. Deuteration experiments and kinetic isotope effect measurements revealed major mechanistic differences to related Rh

Indexed as

asymmetric catalysisC−C bond activationcyclobutanolsdeuterationiridium

Identifiers

PMID33314360
PMCPMC7986405
OpenAlexW3113331853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.