Evidence map›Paper›PMID 33314321›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2021

Decreased incidence of acute rejection without increased incidence of cytomegalovirus (CMV) infection in kidney transplant recipients receiving rabbit anti-thymocyte globulin without CMV prophylaxis - a cohort single-center study.

Mayara Ivani de Paula, Mary Grace Bowring, Ashton A Shaffer, Jacqueline Garonzik-Wang, Adrieli Barros Bessa, Claudia Rosso Felipe, Marina Pontello Cristelli, Allan B Massie, Jose Medina-Pestana, Dorry L Segev and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Mayara Ivani de PaulaDepartment of Nephrology, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.
Mary Grace BowringDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ashton A ShafferDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jacqueline Garonzik-WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Adrieli Barros BessaDepartment of Nephrology, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.
Claudia Rosso FelipeDepartment of Nephrology, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.
Marina Pontello CristelliDepartment of Nephrology, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID 0000-0002-2813-0400
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jose Medina-PestanaDepartment of Nephrology, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Helio Tedesco-SilvaDepartment of Nephrology, Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil.ORCID 0000-0002-9896-323X
Johns Hopkins University · USHospital do Rim e Hipertensão · BR

Funding

Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Understanding the Impact of HIV on Survival in End-Stage Liver DiseaseF30DK116658 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SHAFFER, ASHTON A · 2017 to 2019
$149k
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil (CAPES) 001National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) F30DK116658National Institute of Diabetes and Digestive and Kidney Disease (NIDDK) K24DK101828NIDDK NIH HHS F30 DK116658NIDDK NIH HHS K24 DK101828NIGMS NIH HHS T32 GM136577
6 · The paper itself

Abstract

Induction therapy with rabbit anti-thymocyte globulin (rATG) in low-risk kidney transplant recipients (KTR) remains controversial, given the associated increased risk of cytomegalovirus (CMV) infection. This natural experiment compared 12-month clinical outcomes in low-risk KTR without CMV prophylaxis (January/3/13-September/16/15) receiving no induction or a single 3 mg/kg dose of rATG. We used logistic regression to characterize delayed graft function (DGF), negative binomial to characterize length of hospital stay (LOS), and Cox regression to characterize acute rejection (AR), CMV infection, graft loss, death, and hospital readmissions. Recipients receiving 3 mg/kg rATG had an 81% lower risk of AR (aHR

Indexed as

Cytomegalovirus InfectionsKidney TransplantationAntilymphocyte SerumCytomegalovirusGraft RejectionHumansImmunosuppressive AgentsIncidenceRetrospective StudiesTransplant RecipientsAntilymphocyte SerumImmunosuppressive Agentsacute rejectionCMV infectionlow immunological riskthymoglobulin

Identifiers

PMID33314321
PMCPMC8573716
OpenAlexW3110905462

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.