ArticleHealth economics review2020
Application study of the EQ-5D-5L in oncology: linking self-reported quality of life of patients with advanced or metastatic colorectal cancer to clinical data from a German tumor registry.
Article in Health economics review, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Supervised Exercise for Patients With Metastatic Breast Cancer: A Cost-Utility Analysis Alongside the PREFERABLE-EFFECT Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025Trial
- Association Between Health-Related Quality of Life In Patients with Colorectal Cancer and Their Informal Caregivers.Advances in therapy · 2026Article
- Impact of Infection Timing on Outcomes: A Comparative Study of Periprosthetic Joint and Fracture-Related Infections.Orthopaedic surgery · 2026Article
- Impairment in quality of life with different sport orthopaedic musculoskeletal injuries-A comprehensive analysis of the German arthroscopy register.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Article
- Impact of unmet needs on health-related quality of life among cancer survivors in Ulsan, Korea.BMC cancer · 2026Article
- Health-related quality of life and associated factors among patients living with epilepsy of Mekelle City Hospitals, Northern Ethiopia: a multicenter observational study.Health and quality of life outcomes · 2026Observational
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- Life after bone infection: a retrospective comparison of quality of life in patients with periprosthetic joint infection and fracture-related infections.Journal of orthopaedic surgery and research · 2025Article
- Health-Related Quality of Life and Patient Experience in Oncology Palliative Care Within the Saudi Model of Care Framework: Evidence from the Qassim Health Cluster, Saudi Arabia.Healthcare (Basel, Switzerland) · 2025Article
- Observational
- Patient-reported outcome measures in penile cancer: a narrative review.International journal of impotence research · 2025Review
- Assessment of Health-Related Quality of Life in Thai Endometrial Cancer Patients: A Comparative Analysis Using EQ5D Utility Scores Across States.Cancer reports (Hoboken, N.J.) · 2025Article
- Quality of life for patients on oncology treatments in the Kingdom of Saudi Arabia: a systematic review.Journal of pharmaceutical policy and practice · 2025Review
- Assessing long-term effectiveness and cost-effectiveness of statin therapy in the UK: a modelling study using individual participant data sets.Health technology assessment (Winchester, England) · 2024Article
- A community-based advanced nurse practitioner-led integrated oncology care model for adults receiving oral anticancer medication: a pilot study.Pilot and feasibility studies · 2024Article
- Primary data on symptom burden and quality of life among elderly patients at risk of dying during unplanned admissions to an NHS hospital: a cohort study using EuroQoL and the integrated palliative care outcome scale.BMC palliative care · 2024Article
- Patient preferences, regret, and health-related quality of life among older adults with acute myeloid leukemia: A pilot longitudinal study.Journal of geriatric oncology · 2023Article
- Cancer Patients' Satisfaction with In-Home Palliative Care and Its Impact on Disease Symptoms.Healthcare (Basel, Switzerland) · 2023Article
- Physical and Quality of Life Changes in Elderly Patients after Laparoscopic Surgery for Colorectal Cancer-A Prospective Cohort Study.International journal of environmental research and public health · 2022Article
- Quality of life of patients with hematological malignancies and factors affecting health state utility values.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe EQ-5D-5L questionnaire is used in oncology to generate health-related quality of life (HRQoL) weights and corresponding health states. The purpose was to explore the relationship between demographic and clinical characteristics and HRQoL among advanced or metastatic colorectal cancer (CRC) patients by linking clinical data of a German CRC registry to self-reported HRQoL measures from the EQ-5D-5L.
methodsThe study sample included patients with advanced or metastatic CRC currently recruited in the German Tumor Registry Colorectal Cancer. The EQ-5D-5L was administered once to patients who were at the start or at later stages of palliative treatment. Data on comorbidities, disease-specific health states, symptoms, and treatment status were drawn from the registry. Multivariate regression analyses were performed to explore the impact of patient and disease characteristics on HRQoL.
resultsIn total, n = 433 questionnaires were included in the data analysis. Mean age of patients was 66.3 years and 61.2% were male. The mean EQ-5D-5L utility score was 0.82 and the mean EQ-5D-5L VAS score was 62.05. The regression analyses revealed that none of the demographic characteristics and few of the clinical characteristics, such as fatigue and pain, had a significant impact on the HRQoL.
conclusionsThe study demonstrated a reduced HRQoL of patients with advanced or metastatic CRC when compared to the general population. The symptoms fatigue and pain negatively affected the HRQoL, whereas other characteristics such as age, gender, and comorbidities did not have a significant impact on HRQoL.
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