Evidence map›Paper›PMID 33313947›Full record

ArticleMolecular medicine reports2021

Sericin inhibits MDA‑MB‑468 cell proliferation via the PI3K/Akt pathway in triple‑negative breast cancer.

Lin Niu, Songhe Yang, Xueying Zhao, Xiaochao Liu, Lina Si, Meng Wei, Lei Liu, Luyang Cheng, Yuebing Qiao, Zhihong Chen

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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  3. Article
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  5. Review
  6. The NaturalInternational journal of molecular sciences · 2025
    Article
  7. Article
  8. Anti-cancer agents in medicinal chemistry · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Lin Niu *Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Songhe Yang *Department of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Xueying ZhaoDepartment of Immunology, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Xiaochao LiuDepartment of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Lina SiDepartment of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Meng WeiDepartment of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Lei LiuDepartment of Immunology, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Luyang ChengDepartment of Immunology, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Yuebing QiaoDepartment of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Zhihong ChenDepartment of Human Anatomy, Chengde Medical University, Chengde, Hebei 067000, P.R. China.
Chengde Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple negative breast cancer (TNBC) is a subtype of breast cancer characterized by an aggressive histology and poor prognosis, with limited treatment options in the clinic. In the present study, the effect of sericin, as an anti‑cancer drug, on TNBC cell proliferation was investigated using a MTT assay, a colony formation assay and immunocytochemistry staining of Ki67. Results from the flow cytometry demonstrated that sericin induced G

Indexed as

Antineoplastic AgentsApoptosisCell Cycle CheckpointsCell Line, TumorCell ProliferationComputational BiologyDatabases, GeneticDown-RegulationFemaleGene Expression Regulation, NeoplasticHumansPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSericinsSignal TransductionTriple Negative Breast NeoplasmsAntineoplastic AgentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktSericinscell proliferationMDA‑MB‑468PI3K/Akt signaling pathwaysericintriple negative breast cancer

Identifiers

PMID33313947
PMCPMC7751468
OpenAlexW3113360280

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.