ArticleMolecular biology and evolution2021
Genome Reduction Is Associated with Bacterial Pathogenicity across Different Scales of Temporal and Ecological Divergence.
Article in Molecular biology and evolution, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Antimicrobial Resistance and Genomic Characterization of a Novel ST181Antibiotics (Basel, Switzerland) · 2026Article
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- Deciphering the pangenome of the shellfish pathogenMicrobial genomics · 2026Article
- The Evolutionary and Ecological Consequences of Cooperation.The American naturalist · 2026Review
- The Fires of Isengard Have Spread:Pathogens (Basel, Switzerland) · 2026Article
- Exploring the IS-capades ofMicrobial genomics · 2026Article
- Streptococcus suis avian expansion suggests shared antibiotic use drives host jumps.BMC biology · 2025Article
- Enhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei.Nature communications · 2025Article
- Pan-immune system, mobilome and resistome inMicrobial genomics · 2025Article
- Conserved Heterochromatin-like Structures with Local Regulators Mediate the Iron Stress Response in Mycobacteria.bioRxiv : the preprint server for biology · 2025Article
- Evolutionary dynamics in the genome of ocularMicrobial genomics · 2025Article
- A phylogenetic approach to comparative genomics.Nature reviews. Genetics · 2025Review
- Comparative genomics of endophytic fungi Apiospora malaysiana with related ascomycetes indicates adaptation attuned to lifestyle choices with potential sustainable cellulolytic activity.DNA research : an international journal for rapid publication of reports on genes and genomes · 2025Article
- Phenotypic and genetic heterogeneity ofMicrobial genomics · 2025Article
- Comparative genomics and virulence potential of Campylobacter coli strains isolated from different sources over 25 years in Brazil.BMC microbiology · 2024Article
- Convergent reductive evolution in bee-associated lactic acid bacteria.Applied and environmental microbiology · 2024Article
- Genomic and functional divergence ofMicrobiology spectrum · 2024Article
- Variation in bacterial pathotype is consistent with the sit-and-wait hypothesis.Microbiology (Reading, England) · 2024Article
- Queuosine salvage inMicrobiology (Reading, England) · 2024Article
- Convergent reductive evolution in bee-associated lactic acid bacteria.bioRxiv : the preprint server for biology · 2024Article
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9 authors.
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Abstract
Emerging bacterial pathogens threaten global health and food security, and so it is important to ask whether these transitions to pathogenicity have any common features. We present a systematic study of the claim that pathogenicity is associated with genome reduction and gene loss. We compare broad-scale patterns across all bacteria, with detailed analyses of Streptococcus suis, an emerging zoonotic pathogen of pigs, which has undergone multiple transitions between disease and carriage forms. We find that pathogenicity is consistently associated with reduced genome size across three scales of divergence (between species within genera, and between and within genetic clusters of S. suis). Although genome reduction is also found in mutualist and commensal bacterial endosymbionts, genome reduction in pathogens cannot be solely attributed to the features of their ecology that they share with these species, that is, host restriction or intracellularity. Moreover, other typical correlates of genome reduction in endosymbionts (reduced metabolic capacity, reduced GC content, and the transient expansion of nonfunctional elements) are not consistently observed in pathogens. Together, our results indicate that genome reduction is a consistent correlate of pathogenicity in bacteria.
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