Evidence map›Paper›PMID 33313841›Full record

ArticleThe Journal of clinical endocrinology and metabolism2021

Placental Corticotrophin-Releasing Hormone is a Modulator of Fetal Liver Blood Perfusion.

Satoru Ikenoue, Feizal Waffarn, Masanao Ohashi, Mamoru Tanaka, Daniel L Gillen, Claudia Buss, Sonja Entringer, Pathik D Wadhwa

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Glucocorticoid trajectories in preterm infants-born too soon, wired differently.The Journal of clinical endocrinology and metabolism · 2026
    Article
  3. Article
  4. Article
  5. Origins of obesity in the womb: Fetal adiposity and its determinants.The journal of obstetrics and gynaecology research · 2024
    Review
  6. Development and function of the fetal adrenal.Reviews in endocrine & metabolic disorders · 2023
    Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Satoru IkenoueDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, CA 92697, USA.
Feizal WaffarnDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, CA 92697, USA.
Masanao OhashiDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, CA 92697, USA.
Mamoru TanakaDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo, Japan.
Daniel L GillenDepartment of Statistics, University of California, Irvine, Irvine, CA, USA.
Claudia BussDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, CA 92697, USA.
Sonja EntringerDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, CA 92697, USA.
Pathik D WadhwaDevelopment, Health and Disease Research Program, University of California, Irvine, Irvine, CA 92697, USA.
University of California, Irvine · USKeio University · JPUniversity of Miyazaki · JP

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
EMA Assessment of Biobehavioral Processes in Human PregnancyR01HD060628 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WADHWA, PATHIK D · 2010 to 2014
$3.4M
FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAINR01MH091351 · NIMH · UNIVERSITY OF CALIFORNIA-IRVINE · PI BUSS, CLAUDIA, WADHWA, PATHIK D · 2011 to 2015
$3.3M
Prenatal stress biology, infant body composition and obesity riskR01HD065825 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2010 to 2014
$2.2M
NCATS NIH HHS UL1 TR001414NICHD NIH HHS R01 HD060628NICHD NIH HHS R01 HD065825NIMH NIH HHS R01 MH091351
6 · The paper itself

Abstract

contextVariation in fetal liver blood flow influences fetal growth and postnatal body composition. Placental corticotrophin-releasing hormone has been implicated as a key mediator of placental-fetal perfusion.

objectiveTo determine whether circulating levels of placental corticotrophin-releasing hormone across gestation are associated with variations in fetal liver blood flow.

designProspective cohort study.

methodsFetal ultrasonography was performed at 30 weeks' gestation to characterize fetal liver blood flow (quantified by subtracting ductus venosus flow from umbilical vein flow). Placental corticotrophin-releasing hormone was measured in maternal circulation at approximately 12, 20, and 30 weeks' gestation. Multiple regression analysis was used to determine the proportion of variation in fetal liver blood flow explained by placental corticotrophin-releasing hormone. Covariates included maternal age, parity, pre-pregnancy body mass index, gestational weight gain, and fetal sex.

resultsA total of 79 uncomplicated singleton pregnancies were analyzed. Fetal liver blood flow was 68.4 ± 36.0 mL/min (mean ± SD). Placental corticotrophin-releasing hormone concentrations at 12, 20, and 30 weeks were 12.5 ± 8.1, 35.7 ± 24.5, and 247.9 ± 167.8 pg/mL, respectively. Placental corticotrophin-releasing hormone at 30 weeks, but not at 12 and 20 weeks, was significantly and positively associated with fetal liver blood flow at 30 weeks (r = 0.319; P = 0.004) and explained 10.4% of the variance in fetal liver blood flow.

conclusionsPlacental corticotrophin-releasing hormone in late gestation is a possible modulator of fetal liver blood flow and may constitute a biochemical marker in clinical investigations of fetal growth and body composition.

Indexed as

AdultCohort StudiesCorticotropin-Releasing HormoneFemaleFetal BloodHumansLiverPlacentaPlacental CirculationPregnancyProspective StudiesUltrasonography, PrenatalYoung AdultCorticotropin-Releasing Hormonefetal liver blood flowfetal ultrasonographyPlacental corticotrophin-releasing hormonethird trimester of gestationuncomplicated pregnancy

Identifiers

PMID33313841
PMCPMC7947764
OpenAlexW3112997206

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.