ArticleNeurosurgery2021
Aneurysmal Subarachnoid Hemorrhage: Trends, Outcomes, and Predictions From a 15-Year Perspective of a Single Neurocritical Care Unit.
Article in Neurosurgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Intrathecal nicardipine for cerebral vasospasm after non-traumatic subarachnoid hemorrhage: a meta-analysis.Neurosurgical review · 2025Pooled it
- Clinical severity of aneurysmal subarachnoid hemorrhage over time: systematic review.Neurosurgical review · 2024Pooled it
- Oral Nimodipine in Aneurysmal Subarachnoid Hemorrhage: A Critical Propensity Score-Matched Reevaluation in a Contemporary Cohort.Neurology and therapy · 2026Article
- Review
- Multiscale Architecture Governs Stability in Suction-Actuated Variable Stiffness Catheters.Journal of biomechanical engineering · 2026Article
- Medical Complications After Aneurysmal Subarachnoid Hemorrhage: Analysis of Trends in US Admissions from 2006 to 2022.Neurocritical care · 2026Article
- The Impact of Near-Infrared Spectroscopy in Early Detection of Cerebral Deterioration After Aneurysmal Subarachnoid Haemorrhage.Journal of clinical medicine · 2026Article
- Overprediction of mortality with the Hunt and Hess score in aneurysmal subarachnoid hemorrhage: retrospective multicenter study.Critical care science · 2026Article
- Prognosis of subarachnoid hemorrhage determined by intracranial pressure thresholds.Journal of cerebrovascular and endovascular neurosurgery · 2025Article
- Volumetric blood cutoff for outcome prediction in aneurysmal subarachnoid hemorrhage using semiautomated quantification.European journal of medical research · 2025Article
- PANTHER: Prasugrel-based aneurysm treatment with non-identical telescoping with flow diversion with hydrophilic polymer coating for endovascular reconstruction in acute subarachnoid hemorrhage.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Eighteen-Year Trends in Subarachnoid Hemorrhage Management and Outcomes: A Single-Center Experience.Neurocritical care · 2025Observational
- Multi-class subarachnoid hemorrhage severity prediction: addressing challenges in predicting rare outcomes.Neurosurgical review · 2025Article
- Dynamic Rigidity Control for Supportive Sheaths in Endovascular Procedures.Journal of biomechanical engineering · 2025Article
- Jugular Venous Catheterization is Not Associated with Increased Complications in Patients with Aneurysmal Subarachnoid Hemorrhage.Neurocritical care · 2025Article
- National trends in surgical treatment and clinical outcomes among patients with aneurysmal subarachnoid hemorrhage in the Republic of Korea.Journal of cerebrovascular and endovascular neurosurgery · 2025Article
- Development and Validation of Machine Learning Models for Outcome Prediction in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage Following Endovascular Treatment.Therapeutics and clinical risk management · 2025Article
- Multidimensional outcome after endovascular or microsurgical occlusion of ruptured intracranial aneurysms - Comparative analysis of a prospective Swiss multicenter study.Brain & spine · 2025Article
- Code Status Transitions of Patients with Aneurysmal Subarachnoid Hemorrhage in the Intensive Care Unit.Palliative medicine reports · 2025Article
- Pharmacologic Venous Thromboembolism Prophylaxis in Patients with Nontraumatic Subarachnoid Hemorrhage Requiring an External Ventricular Drain.Neurocritical care · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundAneurysmal subarachnoid hemorrhage (aSAH) is associated with disproportionally high mortality and long-term neurological sequelae. Management of patients with aSAH has changed markedly over the years, leading to improvements in outcome.
objectiveTo describe trends in aSAH care and outcome in a high-volume single center 15-yr cohort.
methodsAll new admissions diagnosed with subarachnoid hemorrhage (SAH) to our tertiary neuro-intensive care unit between 2002 and 2016 were reviewed. Trend analysis was performed to assess temporal changes and a step-wise regression analysis was done to identify factors associated with outcomes.
resultsOut of 3970 admissions of patients with SAH, 2475 patients proved to have a ruptured intracranial aneurysm. Over the years of the study, patient acuity increased by Hunt & Hess (H&H) grade and related complications. Endovascular therapies became more prevalent over the years, and were correlated with better outcome. Functional outcome overall improved, yet the main effect was noted in the low- and intermediate-grade patients. Several parameters were associated with poor functional outcome, including long-term mechanical ventilation (odds ratio 11.99, CI 95% [7.15-20.63]), acute kidney injury (3.55 [1.64-8.24]), pneumonia (2.89 [1.89-4.42]), hydrocephalus (1.80 [1.24-2.63]) diabetes mellitus (1.71 [1.04-2.84]), seizures (1.69 [1.07-2.70], H&H (1.67 [1.45-1.94]), and age (1.06 [1.05-1.07]), while endovascular approach to treat the aneurysm, compared with clip-ligation, had a positive effect (0.35 [0.25-0.48]).
conclusionThis large, single referral center, retrospective analysis reveals important trends in the treatment of aSAH. It also demonstrates that despite improvement in functional outcome over the years, systemic complications remain a significant risk factor for poor prognosis. The historic H&H determination of outcome is less valid with today's improved care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.