Evidence map›Paper›PMID 33313784›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021

Sleep-Disordered Breathing Is Associated With Impaired Odor Identification in Older U.S. Adults.

Jesse K Siegel, Xiandao Yuan, Kristen E Wroblewski, Martha K McClintock, Jayant M Pinto

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Olfactory dysfunction is associated with cognitive impairment in patients with obstructive sleep apnea: a cross-sectional study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Jesse K SiegelPritzker School of Medicine, The University of Chicago, Illinois.
Xiandao YuanDepartment of Otolaryngology-Head and Neck Surgery, Beijing An Zhen Hospital, Capital Medical University, China.
Kristen E WroblewskiDepartment of Public Health Sciences, The University of Chicago, Illinois.
Martha K McClintockDepartment of Psychology and The Institute for Mind and Biology, The University of Chicago, Illinois.
Jayant M PintoSection of Otolaryngology-Head and Neck Surgery, Department of Surgery, The University of Chicago Medicine, Illinois.
University of Chicago · USCapital Medical University · CNChicago Department of Public Health · US

Funding

National Social Life, Health, and Aging Project: Round 5R01AG048511 · NIA · NATIONAL OPINION RESEARCH CENTER · PI LINDA J WAITE · 2014 to 2026
$49.5M
National Social Life, Health and Aging: Wave 4R01AG043538 · NIA · NATIONAL OPINION RESEARCH CENTER · PI LINDA J WAITE · 2013 to 2026
$42.7M
National Social Life, Health, and Aging Project: Anaylsis of Wave 1 and Wave 2R37AG030481 · NIA · NATIONAL OPINION RESEARCH CENTER · PI WAITE, LINDA J · 2008 to 2017
$15.4M
NIA NIH HHS R01 AG043538NIA NIH HHS R01 AG048511NIA NIH HHS R37 AG030481
6 · The paper itself

Abstract

backgroundSleep-disordered breathing (SDB) is a common, underdiagnosed condition in older adults with major health consequences, including disrupted central nervous system functioning. Whether SDB may affect sensory function is unclear. We sought to address this question by comparing 2 forms of olfactory testing which measure peripheral and central olfactory processing.

methodsWe assessed SDB (survey-reported snoring frequency, nighttime apneic events, or diagnosis of sleep apnea) in the National Social Life, Health, and Aging Project, a nationally representative sample of older U.S. adults. Odor sensitivity (peripheral) and odor identification (central) were assessed with validated instruments. Logistic regression was used to test the relationship between SDB and olfaction, accounting for relevant covariates, including demographics, cognition, and comorbidity.

resultsTwenty-nine percent of older U.S. adults reported symptoms of SDB (apneic events or nightly snoring). Of these, only 32% had been diagnosed with sleep apnea. Older adults with SDB (those who reported symptoms or have been diagnosed with sleep apnea) were significantly more likely to have impaired odor identification (odds ratio 2.13, 95% confidence interval 1.19-3.83, p = .012) in analyses that accounted for age, gender, race/ethnicity, education, cognition, comorbidities (including depression), and body mass index. Presence of SDB was not associated with impaired odor sensitivity (odds ratio 1.03, 95% confidence interval 0.75-1.43, p = .84).

conclusionSDB is highly prevalent but underdiagnosed in older U.S. adults and is associated with impaired odor identification but not odor sensitivity. These data support the concept that SDB affects pathways in the central nervous system which involve chemosensory processing.

Indexed as

AgedAged, 80 and overAge FactorsCohort StudiesFemaleHumansMaleMiddle AgedOdds RatioOdorantsOlfaction DisordersRisk FactorsSleep Apnea SyndromesSocioeconomic FactorsSurveys and QuestionnairesUnited StatesCognitive impairmentSleep apneaSmell

Identifiers

PMID33313784
PMCPMC7907488
OpenAlexW3113364376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.