Evidence map›Paper›PMID 33313691›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2021

Sex-specific associations between alcohol consumption, cardiac morphology, and function as assessed by magnetic resonance imaging: insights form the UK Biobank Population Study.

Judit Simon, Kenneth Fung, Márton Kolossváry, Mihir M Sanghvi, Nay Aung, Jose Miguel Paiva, Elena Lukaschuk, Valentina Carapella, Béla Merkely, Marcio S Bittencourt and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Judit SimonMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68. Városmajor Street, 1122, Budapest, Hungary.ORCID 0000-0001-8063-3462
Kenneth FungWilliam Harvey Research Institute, NIHR Biomedical Research Centre at Barts, Queen Mary University of London, London, UK.ORCID 0000-0001-5271-1697
Márton KolossváryMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68. Városmajor Street, 1122, Budapest, Hungary.
Mihir M SanghviWilliam Harvey Research Institute, NIHR Biomedical Research Centre at Barts, Queen Mary University of London, London, UK.ORCID 0000-0002-1914-4149
Nay AungWilliam Harvey Research Institute, NIHR Biomedical Research Centre at Barts, Queen Mary University of London, London, UK.ORCID 0000-0001-5095-1611
Jose Miguel PaivaWilliam Harvey Research Institute, NIHR Biomedical Research Centre at Barts, Queen Mary University of London, London, UK.
Elena LukaschukOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-1729-8918
Valentina CarapellaOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Béla MerkelyMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68. Városmajor Street, 1122, Budapest, Hungary.
Marcio S BittencourtUniversity Hospital, University of São Paulo, São Paulo, SP, Brazil.ORCID 0000-0002-3711-1754
Júlia KarádyMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68. Városmajor Street, 1122, Budapest, Hungary.
Aaron M LeeWilliam Harvey Research Institute, NIHR Biomedical Research Centre at Barts, Queen Mary University of London, London, UK.ORCID 0000-0001-6008-5366
Stefan K PiechnikOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0002-0268-5221
Stefan NeubauerOxford Centre for Clinical Magnetic Resonance Research (OCMR), Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
Pál Maurovich-HorvatMTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, 68. Városmajor Street, 1122, Budapest, Hungary.ORCID 0000-0003-0885-736X
Steffen E PetersenWilliam Harvey Research Institute, NIHR Biomedical Research Centre at Barts, Queen Mary University of London, London, UK.ORCID 0000-0003-4622-5160
Queen Mary University of London · GBSemmelweis University · HUJohn Radcliffe Hospital · GBHospital Universitário da Universidade de São Paulo · BRKing's College London · GB

Funding

British Heart Foundation PG/14/89/31194Medical Research Council MC_PC_17228Medical Research Council MC_QA137853Medical Research Council MR/L016311/1Wellcome Trust 203553Wellcome Trust 203553/Z/16/Z
6 · The paper itself

Abstract

aimsData regarding the effects of regular alcohol consumption on cardiac anatomy and function are scarce. Therefore, we sought to determine the relationship between regular alcohol intake and cardiac structure and function as evaluated with cardiac magnetic resonance imaging. METHODS AND

resultsParticipants of the UK Biobank who underwent cardiac magnetic resonance were enrolled in our analysis. Data regarding regular alcohol consumption were obtained from questionnaires filled in by the study participants. Exclusion criteria were poor image quality, missing, or incongruent data regarding alcohol drinking habits, prior drinking, presence of heart failure or angina, and prior myocardial infarction or stroke. Overall, 4335 participants (61.5 ± 7.5 years, 47.6% male) were analysed. We used multivariate linear regression models adjusted for age, ethnicity, body mass index, smoking, hypertension, diabetes mellitus, physical activity, cholesterol level, and Townsend deprivation index to examine the relationship between regular alcohol intake and cardiac structure and function. In men, alcohol intake was independently associated with marginally increased left ventricular end-diastolic volume [β = 0.14; 95% confidence interval (CI) = 0.05-0.24; P = 0.004], left ventricular stroke volume (β = 0.08; 95% CI = 0.03-0.14; P = 0.005), and right ventricular stroke volume (β = 0.08; 95% CI = 0.02-0.13; P = 0.006). In women, alcohol consumption was associated with increased left atrium volume (β = 0.14; 95% CI = 0.04-0.23; P = 0.006).

conclusionAlcohol consumption is independently associated with a marginal increase in left and right ventricular volumes in men, but not in women, whereas alcohol intake showed an association with increased left atrium volume in women. Our results suggest that there is only minimal relationship between regular alcohol consumption and cardiac morphology and function in an asymptomatic middle-aged population.

Indexed as

Biological Specimen BanksMagnetic Resonance ImagingAlcohol DrinkingFemaleHeart AtriaHumansMagnetic Resonance SpectroscopyMaleMiddle AgedStroke VolumeUnited KingdomVentricular Function, Leftalcohol consumptioncardiac morphology and structuremagnetic resonance imagingUK Biobank

Identifiers

PMID33313691
PMCPMC7613253
OpenAlexW3117394517

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.