ArticleJNCI cancer spectrum2020
White Blood Cell Count and Risk of Incident Lung Cancer in the UK Biobank.
Article in JNCI cancer spectrum, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Intensive care infection score outperforms inflammatory biomarkers in detecting infection in critically ill patients.Infection · 2026Article
- The impact of inflammation on the incidence of different pathological types of lung cancer: the Kailuan study.Frontiers in oncology · 2026Article
- Diagnostic value of peripheral blood leukocyte parameters, NE-WX, LY-Y, MO-WY, MO-Y, MO-Z, and NE-SFL, in lung cancer.Frontiers in oncology · 2026Article
- Risk Factors Associated With Incidence of Lung Cancer in Never-Smokers: A Systematic Review and Meta-Analysis.JTO clinical and research reports · 2025Article
- T-cell Receptor Profiling of Blood to Detect Lung Cancer.Cancer immunology research · 2025Article
- A Role of Serum Interleukin-39 and Association with Small and Non-Small Cell Carcinoma in Lung Cancer Patients.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- The association between white blood cell count and relative risk of non-small cell lung cancer.Discover oncology · 2025Article
- Machine learning and discriminant analysis model for predicting benign and malignant pulmonary nodules.BMC medical informatics and decision making · 2025Article
- A Cross-Sectional Study of Platelet-to-Lymphocyte Ratio in Relation to Pigment Cell Nevi and Atypical Mole Syndrome.Health science reports · 2025Article
- The Risk Factors for Post-Bronchoscopy Respiratory Infection in Lung Cancer Patients-A Retrospective Case-Control Study from a Center in Greece.Journal of clinical medicine · 2025Article
- White blood cell traits and lung cancer risk: a two-sample mendelian randomization analysis.Scientific reports · 2025Article
- [Research Progress of Tumor-associated Neutrophils in the Occurrence and Development of Lung Cancer].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Review
- Diagnostic accuracy of folate receptor-positive circulating tumor cells in differentiating between benign and malignant pulmonary nodules.Translational cancer research · 2024Article
- DNA Methylation-Derived Immune Cell Proportions and Cancer Risk in Black Participants.Cancer research communications · 2024Article
- Associations between eosinophils and cancer risk in the UK Biobank.International journal of cancer · 2024Article
- Genetic susceptibility to chronic diseases leads to heart failure among Europeans: the influence of leukocyte telomere length.Human molecular genetics · 2024Article
- White Blood Cell Count, Neutrophil-to-Lymphocyte Ratio, and Incident Cancer in the UK Biobank.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Genetic Evidence for a Causal Relationship Between Innate Leukocytes and the Risk of Digestive System Cancers in East Asians and Europeans.World journal of oncology · 2024Article
- DNA Methylation-Derived Immune Cell Proportions and Cancer Risk, Including Lung Cancer, in Black Participants.medRxiv : the preprint server for health sciences · 2024Article
- Age at lung cancer diagnosis in females versus males who never smoke by race and ethnicity.British journal of cancer · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe contribution of measurable immunological and inflammatory parameters to lung cancer development remains unclear, particularly among never smokers. We investigated the relationship between total and differential white blood cell (WBC) counts and incident lung cancer risk overall and among subgroups defined by smoking status and sex in the United Kingdom (UK).
methodsWe evaluated 424 407 adults aged 37-73 years from the UK Biobank. Questionnaires, physical measurements, and blood were administered and collected at baseline in 2006-2010. Complete blood cell counts were measured using standard methods. Lung cancer diagnoses and histological classifications were obtained from cancer registries. Multivariable Cox regression models were used to estimate the hazard ratio (HR) and 95% confidence intervals of incident lung cancer in relation to quartiles (Q) of total WBC and subtype-specific counts, with Q1 as the reference.
resultsThere were 1493 incident cases diagnosed over an average 7-year follow-up. Overall, the highest quartile of total WBC count was statistically significantly associated with elevated lung cancer risk (HR
conclusionsElevated WBCs could potentially be one of many important markers for increased lung cancer risk, especially among never-smoking women and ever-smoking men.
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