Evidence map›Paper›PMID 33313448›Full record

ArticleBioactive materials2021

Modified hyaluronic acid hydrogels with chemical groups that facilitate adhesion to host tissues enhance cartilage regeneration.

Jiaqing Chen, Jiabei Yang, Li Wang, Xuewei Zhang, Boon Chin Heng, Dong-An Wang, Zigang Ge

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed
21.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 231 citations in OpenAlex.

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  9. Spatiotemporal controlled release of YCM/CuJournal of nanobiotechnology · 2026
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32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Jiaqing ChenDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, PR China.
Jiabei YangDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, PR China.
Li WangDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, PR China.
Xuewei ZhangDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, PR China.
Boon Chin HengSchool of Stomatology, Peking University, Beijing, 100081, PR China.
Dong-An WangDepartment of Biomedical Engineering, College of Engineering, City University of Hong Kong, Hong Kong SAR, PR China.
Zigang GeDepartment of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, PR China.
Peking University · CNCity University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stable integration of hydrogel implants with host tissues is of critical importance to cartilage tissue engineering. Designing and fabricating hydrogels with high adhesive strength, stability and regeneration potential are major challenges to be overcome. This study fabricated injectable adhesive hyaluronic acid (HA) hydrogel modified by aldehyde groups and methacrylate (AHAMA) on the polysaccharide backbone with multiple anchoring mechanisms (amide bond through the dynamic Schiff base reaction, hydrogen bond and physical interpenetration). AHAMA hydrogel exhibited significantly improved durability and stability within a humid environment (at least 7 days), together with higher adhesive strength (43 KPa to skin and 52 KPa to glass), as compared to commercial fibrin glue (nearly 10 KPa) and HAMA hydrogel (nearly 20 KPa). The results showed that AHAMA hydrogel was biocompatible and could be easily and rapidly prepared

Indexed as

AdhesionAldehydeCartilage regenerationHyaluronic acidHydrogelSchiff base reaction

Identifiers

PMID33313448
PMCPMC7708943
OpenAlexW3107908934

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.