Evidence map›Paper›PMID 33313396›Full record

ArticleACS biomaterials science & engineering2020

Development of a Sensitive Assay to Screen Nanoparticles

Nuzhat Maisha, Tobias Coombs, Erin Lavik

Abstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Transfusion biomaterials for hemostasis.Journal of thrombosis and haemostasis : JTH · 2025
    Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nuzhat MaishaDepartment of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, Piscataway Territories.
Tobias CoombsDepartment of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, Piscataway Territories.
Erin LavikDepartment of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, Piscataway Territories.

Funding

U-RISE at University of Maryland Baltimore CountyT34GM136497 · NIGMS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI PHYLLIS R ROBINSON · 2020 to 2026
$9.5M
Stopping Bleeding in the Spinal Cord After InjuryR56NS100732 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE COUNTY · PI LAVIK, ERIN BAKER, SILVER, JERRY · 2017 to 2017
$333k
NIGMS NIH HHS T34 GM136497NINDS NIH HHS R56 NS100732
6 · The paper itself

Abstract

Nanomedicines are often recognized by the innate immune system as a threat, leading to unwanted clearance due to complement activation. This adverse reaction not only alters the bioavailability of the therapeutic but can also cause cardiopulmonary complications and death in a portion of the population. There is a need for tools for assessing complement response in the early stage of development of nanomedicines. Currently, quantifying complement-mediated response

Indexed as

Complement ActivationNanoparticlesComplement System ProteinsNanomedicineComplement System Proteinshypersensitivity reactionnanomedicinesafetyscreening tool

Identifiers

PMID33313396
PMCPMC7725268

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.