ArticleACS biomaterials science & engineering2020
Enhancing Collagen Mineralization with Amelogenin Peptide: Towards the Restoration of Dentin.
Article in ACS biomaterials science & engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Self-assembled silk fibroin as an interfacial reinforcer: A synergistic strategy with amorphous calcium phosphate for durable dentin bonding.Materials today. Bio · 2025Article
- Amyloid-induced mineralization: From biological systems to biomimetic materials.Bioactive materials · 2025Review
- The effects and mechanisms underlying collagen-binding peptides MDPs on dentin remineralization: an in vitro study.BMC oral health · 2025Article
- Biomineralization of dental tissues with natural drugs: a comprehensive review.The Saudi dental journal · 2025Review
- Treating White Spot Lesions and Non-Carious Cervical Lesions with Amelogenin Peptide-Based Hydrogel.Biomimetics (Basel, Switzerland) · 2025Article
- A Comparison of the Enamel Remineralisation Potential of Self-Assembling Peptides.International dental journal · 2024Article
- Peptide-Based Biomaterials for Bone and Cartilage Regeneration.Biomedicines · 2024Review
- Triple Function of Amelogenin Peptide-Chitosan Hydrogel for Dentin Repair.Journal of dental research · 2023Article
- Remineralization of Dentinal Lesions Using Biomimetic Agents: A Systematic Review and Meta-Analysis.Biomimetics (Basel, Switzerland) · 2023Review
- Engineered Peptides Enable Biomimetic Route for Collagen Intrafibrillar Mineralization.International journal of molecular sciences · 2023Article
- Biomimetic Dentin Repair: Amelogenin-Derived Peptide Guides Occlusion and Peritubular Mineralization of Human Teeth.ACS biomaterials science & engineering · 2023Article
- Numerical Modeling of a New Type of Prosthetic Restoration for Non-Carious Cervical Lesions.Materials (Basel, Switzerland) · 2022Article
- Promoting mineralization at biological interfacesMaterials today. Bio · 2022Article
- Promoting effect of a calcium-responsive self-assembly β-sheet peptide on collagen intrafibrillar mineralization.Regenerative biomaterials · 2022Article
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Biomineralization of Enamel and Dentin Mediated by Matrix Proteins.Journal of dental research · 2021Review
- Biomineralization of Collagen-Based Materials for Hard Tissue Repair.International journal of molecular sciences · 2021Review
- Amelogenin Peptide-Chitosan Hydrogel for Biomimetic Enamel Regrowth.Frontiers in dental medicine · 2021Article
- Mapping the Inorganic and Proteomic Differences among Different Types of Human Teeth: A Preliminary Compositional Insight.Biomolecules · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian teeth primarily consist of two distinct calcified tissues, enamel and dentin, that are intricately integrated by a complex and critical structure, the dentin-enamel junction (DEJ). Loss of enamel exposes the underlying dentin, increasing the risk of several irreversible dental diseases. This paper highlights the significance of utilizing the functional domains of a major enamel matrix protein, amelogenin, intrinsic to tooth enamel and the DEJ interface, to rationally design smaller bioinspired peptides for regeneration of tooth microstructures. Using this strategy, we designed a synthetic peptide, P26, that demonstrates a remarkable dual mineralization potential to restore incipient enamel decay and mineralization defects localized in peripheral dentin below the DEJ. As a proof of principle, we demonstrate that interaction between P26 and collagen prompts peptide self-assembly, followed by mineralization of collagen fibrils
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.