ArticleAlzheimer's & dementia (New York, N. Y.)2020
Development and validation of language and visuospatial composite scores in ADNI.
Article in Alzheimer's & dementia (New York, N. Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
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- Characterisation of Posterior Predominant Amyloid PET Binding Across Multiple Cohorts.bioRxiv : the preprint server for biology · 2026Article
- Development and validation of a harmonized memory score for multicenter Alzheimer's disease and related dementia research.Alzheimer's research & therapy · 2026Article
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- Differential associations of plasma biomarkers with Alzheimer's disease and small vessel disease: A multimodal imaging study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Social determinants of brain structure and cognition.Social science & medicine (1982) · 2026Article
- Associations between ventricular boundary shift integral and composite cognitive domains across the alzheimer's disease continuum.Scientific reports · 2026Article
- Enhanced sensitivity to plasma p-tau217 with proper names recall in the preclinical Alzheimer's cognitive composite.Brain communications · 2026Article
- Specific atrophy patterns distinguish tau and TDP-43 pathology: a longitudinal MRI ante-mortem study.Acta neuropathologica communications · 2025Article
- Integrating individualized connectome with amyloid pathology improves predictive modeling of future cognitive decline.Communications medicine · 2025Article
- Development of language composites for enhanced sensitivity to multiple plasma biomarkers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Measurement Error and Methodologic Issues in Analyses of the Proportion of Variance Explained in Cognition.Neuropsychology review · 2025Review
- Using Bayesian item response theory for multicohort repeated measure design to estimate individual latent change scores.Psychological methods · 2025Article
- White matter hyperintensity burden predicts domain-specific cognitive decline across the Alzheimer's disease continuum.Scientific reports · 2025Article
- Interplay between astrocyte reactivity and APOE ε4 status is associated with accelerated pTau-related tau pathology in Alzheimer's disease.Molecular neurodegeneration · 2025Article
- Beyond NACC's Uniform Data Set for cognition: the impact of additional items on measurement precision.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- The effect of Lewy body (co-)pathology on the clinical and imaging phenotype of amnestic patients.Brain : a journal of neurology · 2025Article
- Comprehensive Anatomical Staging Predicts Clinical Progression in Mild Cognitive Impairment: A Data-Driven Approach.International journal of molecular sciences · 2025Article
- The associations between cerebral microhemorrhages and cognitive decline across Alzheimer's continuum.Aging clinical and experimental research · 2025Article
2 more citing papers are in PubMed but not listed here.
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21 authors.
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Abstract
introductionComposite scores may be useful to summarize overall language or visuospatial functioning in studies of older adults.
methodsWe used item response theory to derive composite measures for language (ADNI-Lan) and visuospatial functioning (ADNI-VS) from the cognitive battery administered in the Alzheimer's Disease Neuroimaging Initiative (ADNI). We evaluated the scores among groups of people with normal cognition, mild cognitive impairment (MCI), and Alzheimer's disease (AD) in terms of responsiveness to change, association with imaging findings, and ability to differentiate between MCI participants who progressed to AD dementia and those who did not progress.
resultsADNI-Lan and ADNI-VS were able to detect change over time and predict conversion from MCI to AD. They were associated with most of the pre-specified magnetic resonance imaging measures. ADNI-Lan had strong associations with a cerebrospinal fluid biomarker pattern. DISCUSSION: ADNI-Lan and ADNI-VS may be useful composites for language and visuospatial functioning in ADNI.
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