Evidence map›Paper›PMID 33313322›Full record

ArticleBioMed research international2020

A Novel Cryptococcal Meningitis Therapy: The Combination of Amphotericin B and Posaconazole Promotes the Distribution of Amphotericin B in the Brain Tissue.

Ming Yang, Lin Cheng, Qing Dai, Bo Yang, Qian Yuan, MingJie Yu, Wei Feng, Fengjun Sun, Peiyuan Xia

Open access · hybridAbstract read
In one paragraph

Article in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ming YangDepartment of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, China.
Lin ChengDepartment of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID https://orcid.org/0000-0003-3825-5378
Qing DaiDepartment of Pharmacy, The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.ORCID https://orcid.org/0000-0002-6488-8753
Bo YangDepartment of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID https://orcid.org/0000-0002-1748-9514
Qian YuanDepartment of Pharmacy, The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China.ORCID https://orcid.org/0000-0002-7815-5307
MingJie YuDepartment of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID https://orcid.org/0000-0001-8938-5514
Wei FengDepartment of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID https://orcid.org/0000-0003-4513-6684
Fengjun SunDepartment of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID https://orcid.org/0000-0003-2679-8797
Peiyuan XiaDepartment of Pharmacy, The First Affiliated Hospital of Third Military Medical University (Army Medical University), Chongqing 400038, China.ORCID https://orcid.org/0000-0003-3747-5512
Army Medical University · CNAffiliated Hospital of North Sichuan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The deficient brain tissue distribution of amphotericin B (AMPB) seriously restricts its treatment for the clinical efficacy of

Indexed as

Amphotericin BAnimalsATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2Blood-Brain BarrierBrainCryptococcus neoformansDibenzocycloheptenesDiketopiperazinesDisease Models, AnimalHeterocyclic Compounds, 4 or More RingsHumansMaleMeningitis, CryptococcalMiceMolecular Docking Simulation3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl esterAbcg2 protein, mouseAmphotericin BATP Binding Cassette Transporter, Subfamily B, Member 1ATP Binding Cassette Transporter, Subfamily G, Member 2DibenzocycloheptenesDiketopiperazinesHeterocyclic Compounds, 4 or More RingsposaconazoleQuinolinesSerum AlbuminTriazoleszosuquidar trihydrochloride

Identifiers

PMID33313322
PMCPMC7719495
OpenAlexW3108716832

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.