ArticleAnnals of translational medicine2020
Hyperion imaging system reveals heterogeneous tumor microenvironment of oral squamous cell carcinoma patients at T1N0M0 stage.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Oral Cancer-Derived miR-762 Suppresses T-Cell Infiltration and Activation by Horizontal Inhibition of CXCR3 Expression.International journal of molecular sciences · 2025Article
- [Application value of whole exon sequencing and immune related indicators in the precision treatment of oral squamous cell carcinoma].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023Article
- A convolutional neural network STIFMap reveals associations between stromal stiffness and EMT in breast cancer.Nature communications · 2023Article
- Bioinformatics based exploration of hsa-miR-194-5p regulation of CHD4 through PI3K/AKT signal pathway to enhance tumor resistance to apoptosis due to loss of nests and participate in poor prognosis of oral squamous cell carcinoma.Annals of translational medicine · 2023Article
- The Role of Pathology-Based Methods in Qualitative and Quantitative Approaches to Cancer Immunotherapy.Cancers · 2022Review
- An overview of multiplexed analyses of CAR T-cell therapies: insights and potential.Expert review of proteomics · 2021Article
- High Dimensional Imaging Mass Cytometry Panel to Visualize the Tumor Immune Microenvironment Contexture.Frontiers in immunology · 2021Article
- Hyperion Image Analysis Depicts a Preliminary Landscape of Tumor Immune Microenvironment in OSCC with Lymph Node Metastasis.Journal of immunology research · 2021Article
- Targeting Neuroinflammation in Brain Cancer: Uncovering Mechanisms, Pharmacological Targets, and Neuropharmaceutical Developments.Frontiers in pharmacology · 2021Review
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Authors and funding
7 authors.
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Abstract
backgroundOral squamous cell carcinoma (OSCC) is a highly heterogeneous neoplasm where the identification of heterogeneity is a critical clinical need to improve treatment planning and prognosis prediction. Utilizing the Hyperion imaging system to carry out high-dimensional proteomics analysis on the heterogeneity of tumor samples, this study aims to detect and analyze the heterogeneity of OSCC without lymph node metastasis and explore potential contributing factors for poor prognosis of early-stage OSCC.
methodsWe collected tumor tissue samples from four OSCC patients at the T1N0M0 stage, who presented with similar clinical manifestations. Patient formalin-fixed, paraffin-embedded (FFPE) tissue sections were prepared and stained using a panel of 26 immune or tumor-related antibodies. Different metal tags were assigned to each antibody. The stained cells were then detected and analyzed by the Hyperion imaging system.
resultsTumor samples of four OSCC patients presenting with similar clinical characteristics at the T1N0M0 stage had different cell subtypes, including CD4
conclusionsHigh-dimensional proteomics analyses using the Hyperion imaging system help identify and analyze the tumor microenvironment heterogeneity of OSCC. Our study now presents this valuable resource and explains the potential reasons behind early OSCC patients' poor prognosis.
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