ArticleAnnals of translational medicine2020
Comparison of topological properties of functional brain networks with graph theory in temporal lobe epilepsy with different duration of disease.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Volumetric and functional connectivity alterations of the thalamus and thalamic nuclei groups in drug-resistant focal epilepsy: A 7T MRI study.Neuroradiology · 2026Article
- Investigating topological alterations in procedural memory network across neuropsychiatric disorders using rs-fMRI and graph theory.BMC neuroscience · 2025Article
- High-altitude exposure leads to increased modularity of brain functional network with the increased occupation of attention resources in early processing of visual working memory.Cognitive neurodynamics · 2024Article
- Similarities and differences of dynamic and static spontaneous brain activity between left and right temporal lobe epilepsy.Brain imaging and behavior · 2024Article
- Shared functional network abnormality in patients with temporal lobe epilepsy and their siblings.CNS neuroscience & therapeutics · 2023Article
- A study of brain functional network and alertness changes in temporal lobe epilepsy with and without focal to bilateral tonic-clonic seizures.BMC neurology · 2022Article
- More than just statics: Static and temporal dynamic changes in intrinsic brain activity in unilateral temporal lobe epilepsy.Frontiers in human neuroscience · 2022Article
- The cumulative impact of seizures: the science underlying how seizures beget seizures.Frontiers in neurologyReview
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOur study was performed to measure the alterations in topological properties of the functional brain network of temporal lobe epilepsy (TLE) at different durations, exploring the potential progression and neuropathophysiological mechanisms of TLE.
methodsFifty-eight subjects, including 17 TLE patients with a disease duration of ≤5 years (TLE-SD), 20 TLE patients with a disease duration of >5 years (TLE-LD), and 21 healthy controls firstly underwent the Attention Network Test (ANT) to assess the alertness function and received the resting-state functional magnetic resonance imaging (rs-fMRI). Next, a functional brain network was set up, and then the related graph of theoretical network analysis was conducted. Finally, the correlation between network property and the neuropsychological score was analyzed.
resultsThe global and local efficiencies of functional brain networks in TLE-SD patients significantly decreased and tended toward random alterations. Also, the degree centrality (DC) and nodal efficiency (Ne) in right medial pre-frontal thalamus (mPFtha) and right rostral temporal thalamus (rTtha) of TLE-SD patients significantly reduced. Further analysis showed that alertness was positively associated with the characteristic path length but negatively related to the global and local efficiencies in TLE-SD patients; alertness was negatively related to the Ne of mPFtha in TLE-LD patients.
conclusionsOur study showed that the functional brain network of TLE patients might undergo compensatory reorganization as the disease progresses, which provides useful insights into the progression and mechanism of TLE.
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