Evidence map›Paper›PMID 33313183›Full record

ArticleAnnals of translational medicine2020

Proton pump inhibitors and the risk of hospital-acquired acute kidney injury in children.

Yanqin Li, Mengqi Xiong, Minliang Yang, Long Wang, Sheng Nie, Diankun Liu, Mingjing Pi, Aihua Zhang, Jianhua Mao, Hai-Peng Liu and 24 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors at 14 institutions in 1 country.

Yanqin LiNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Mengqi XiongNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Minliang YangNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Long WangNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Sheng NieNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Diankun LiuNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Mingjing PiNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Aihua ZhangChildren's Hospital of Nanjing Medical University, Nanjing, China.
Jianhua MaoChildren Hospital of Zhejiang University, Hangzhou, China.
Hai-Peng LiuAnhui Institute of Pediatric Research, Anhui Provincial Children's Hospital, Hefei, China.
Huimin XiaGuangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China.
Hong XuChildren's Hospital of Fudan University, Shanghai, China.
Zhangsuo LiuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Shipin FengChengdu Women and Children's Central Hospital, Chengdu, China.
Wei ZhouShanghai Children's Medical Center, Shanghai Jiao Tong University, Shanghai, China.
Xuemei LiuJinan Children's Hospital, Jinan, China.
Yonghong YangPediatric Medical Research Center, Gansu Province Child's Hospital, Lanzhou University Second Hospital, Lanzhou, China.
Yuhong TaoWest China Second University Hospital, Sichuan University, Chengdu, China.
Yunlin FengSichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Chunbo ChenGuangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Mo WangChildren's Hospital of Chongqing Medical University, Chongqing, China.
Yan ZhaGuizhou Provincial People's Hospital, Guizhou University, Guiyang, China.
Jian-Hua FengThe Second Affiliated Hospital, Zhejiang University, Hangzhou, China.
Qingchu LiGuilin Medical University Affiliated Hospital, Guilin, China.
Shuwang GeTongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jianghua ChenKidney Disease Center, the First Affiliated Hospital, Zhejiang University, Hangzhou, China.
Yongcheng HeCenter for Nephrology and Urology Shenzhen University, the First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen, China.
Siyuan TengThe Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Chuanming HaoHuashan Hospital, Fudan University, Shanghai, China.
Bi-Cheng LiuInstitute of Nephrology, Zhong Da Hospital, Nanjing, China.
Ying TangSun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Wenjuan HeNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Fan Fan HouNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Xin XuNational Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Nanfang Hospital · CNSouthern Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CNAnhui Provincial Children's Hospital · CNFirst Affiliated Hospital of Zhengzhou University · CNGuangzhou Medical University · CNChengdu Women's and Children's Central Hospital · CNChildren's Hospital of Fudan University · CNChildren's Hospital of Zhejiang University · CNChongqing Medical University · CNGuilin Medical University · CNSecond Affiliated Hospital of Dalian Medical University · CNShanghai Jiao Tong University · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the association between use of proton pump inhibitor (PPI) and the risk of hospital-acquired acute kidney injury (HA-AKI) in hospitalized children.

methodsWe conducted a multicenter retrospective cohort study in hospitalized children aged 1 month to 18 years from 25 tertiary hospitals across China from 2013 to 2015. Patient-level data were obtained from the electronic hospitalization databases. AKI was defined and staged using the serum creatinine (SCr) data according to the Kidney Disease Improving Global Outcomes (KDIGO) criteria.

resultsAmong 42,232 children analyzed, 11,496 (27.2%) used PPI, 1,760 (4.2%) used histamine 2 receptor antagonist (H2RA), and 3,514 (8.3%) had HA-AKI during hospitalization. Over 85% of PPIs were prescribed for prophylaxis of gastro-duodenal lesions in children. The use of PPI was associated with a significantly increased risk of HA-AKI compared with both non-users [odds ratio (OR), 1.37; 95% confidence interval (CI), 1.23-1.53)] and H2RA users (OR, 1.24; 95% CI, 1.01-1.52). The associations were consistent across children of different age range, gender, subtypes of PPIs and methods of administration. A larger effect was observed in children with chronic kidney disease (OR, 3.37; 95% CI, 2.46-4.62) and those needed intensive care (OR, 1.54; 95% CI, 1.33-1.78). The risk of HA-AKI was increased even within the recommended dosage range of PPI.

conclusionsPPIs were widely used and associated with an increased risk of HA-AKI in hospitalized children in China.

Indexed as

hospital-acquired acute kidney injury (HA-AKI)nephrotoxicitypediatricsProton pump inhibitors (PPIs)

Identifiers

PMID33313183
PMCPMC7723554
OpenAlexW3085833100

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.