ArticleAnnals of translational medicine2020
Incidence trends and survival outcomes of penile squamous cell carcinoma: evidence from the Surveillance, Epidemiology and End Results population-based data.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Survivin and Ki-67 immunohistochemical expression in penile squamous cell carcinoma: clinicopathological features and overall survival.International urology and nephrology · 2026Article
- Efficacy and safety of immune checkpoint inhibitors in metastatic penile squamous cell carcinoma: a retrospective multicenter analysis.Experimental hematology & oncology · 2025Article
- The necessity and challenges of human papillomavirus testing for men.Frontiers in cellular and infection microbiology · 2025Review
- Body mass index and penile cancer incidence: results from a Norwegian cohort study of 829,081 men.BMC urology · 2024Article
- A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
- Racial differences in survival for early stage (T1) penile cancer: Analysis from the SEER database.Urologic oncology · 2023Article
- The relationship of human papillomavirus positivity with tumor characteristics in an Irish penile cancer population.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2022Article
- Clinical and Novel Biomarkers in Penile Carcinoma: A Prospective Review.Journal of personalized medicine · 2022Review
- Trends in Incidence, Mortality, and Survival of Penile Cancer in the United States: A Population-Based Study.Frontiers in oncology · 2022Article
- Emerging Therapies in Penile Cancer.Frontiers in oncology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo provide the latest incidence trends and explore survival outcomes of penile squamous cell carcinoma (PSCC) patients with or without a previous primary malignancy.
methodsPatients diagnosed with PSCC between 1975 and 2016 in the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively included. Then, we calculated the age-adjusted incidence rates (IRs) and annual percentage changes (APCs). Multivariate Cox analysis and Kaplan-Meier (KM) survival curves were conducted to investigate prognostic variables for cancer-specific survival (CSS).
resultsA total of 6,122 PSCC patients were enrolled, 1,137 of whom had a prior malignancy. The age-adjusted IR for the general population in men declined before 1987, fluctuated slightly between 1987 and 1997, and showed an upward trend after 1997, which was basically consistent with that in patients without a previous primary malignancy. The incidence trend of PSCC in the general population was similar with that in those without a previous malignancy. However, the IRs of PSCC in men with a previous malignancy have been increasing since 1975 regardless of race. Furthermore, age at diagnosis, pathological grade, extent of disease, marital status, the administration of surgery and presence of previous primary malignancy were identified to be significantly related to CSS.
conclusionsThe IRs of PSCC have been increasing in recent years. Several independent prognostic factors for CSS were identified, allowing surgeons to assess the individualized risk in advance.
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