ArticleAnnals of translational medicine2020
Sphincter of Oddi laxity alters bile duct microbiota and contributes to the recurrence of choledocholithiasis.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- MICRObiota on BILIOpancreatic malignant diseases [MICROBILIO]: A systematic review.Clinics (Sao Paulo, Brazil) · 2022Pooled it
- Microbiome: a driver of pancreatic inflammation and tumorigenesis.Trends in cancer · 2026Review
- Biliary tract microbes and common bile duct stones: current status and prospects.Frontiers in microbiology · 2026Review
- Microbiota in cholestatic diseases: crosstalk among bile composition, the biliary microbiome, and host immunity.Frontiers in immunology · 2026Review
- Integrating multi-omics in bile for biomarker discovery in cholangiocarcinoma.Hepatology communications · 2025Article
- Improved outcomes and prognostic risk prediction for laparoscopic common bile duct exploration with primary closure versus T-tube drainage.American journal of translational research · 2025Article
- Characterization of biliary and duodenal microbiota in patients with primary and recurrent choledocholithiasis.Health information science and systems · 2024Article
- Laparoscopic cholecystectomy plus common bile duct exploration for extrahepatic bile duct stones and postoperative recurrence-associated risk factors.World journal of gastrointestinal surgery · 2024Article
- How traditional Chinese medicine can prevent recurrence of common bile duct stones after endoscopic retrograde cholangiopancreatography?Frontiers in pharmacology · 2024Review
- Inflammation-associated ectopic mineralization.Fundamental research · 2023Review
- Gastrointestinal microbiome and cholelithiasis: Current status and perspectives.World journal of gastroenterology · 2023Review
- Characteristics and metabolic potential of biliary microbiota in patients with giant common bile duct stones.Frontiers in cellular and infection microbiology · 2023Article
- New common bile duct morphological subtypes: Risk predictors of common bile duct stone recurrence.World journal of gastrointestinal surgery · 2022Article
- Effect of sphincter of Oddi dysfunction on the abundance of biliary microbiota (biliary microecology) in patients with common bile duct stones.Frontiers in cellular and infection microbiology · 2022Article
- Article
- Common bile duct morphology is associated with recurrence of common bile duct stones in Billroth II anatomy patients.World journal of clinical cases · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholedocholithiasis is closely associated with bacterial infection and inflammation in the bile duct. Our previous studies showed that sphincter of Oddi laxity (SOL) significantly altered the bile microbiota and might contribute to the recurrence of biliary stones. However, the direct association among SOL, the bile microbiota, and choledocholithiasis recurrence is unclear.
methodsWe prospectively recruited 202 patients with choledocholithiasis, and obtained bile samples from the common bile duct. We performed 16S ribosomal RNA gene analysis to characterize the bile microbiota and analyzed the risk factors for choledocholithiasis.
resultsDistinct bile microbial communities were identified in patients with and without SOL, with a significantly larger abundance of
conclusionsCholedocholithiasis patients with and without SOL demonstrated significant differences in their microbial communities. SOL is a critical risk factor for the recurrence of choledocholithiasis after surgery. The presence of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.