ArticleAnnals of translational medicine2020
Efficacy of the levonorgestrel-releasing intrauterine device is associated with different subtypes of adenomyosis: a retrospective study.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Evaluation of pharmacological interventions in the management of adenomyosis: a systematic review.European journal of clinical pharmacology · 2022Pooled it
- Analysis of Non-responders to LNG-IUS in Cases of Heavy Menstrual Bleeding.Journal of obstetrics and gynaecology of India · 2026Article
- Three-dimensional characterization of adenomyosis in female mice: Toward a novel system for drug efficacy evaluation.Journal of the Endocrine Society · 2026Article
- Spontaneous Fracture of Copper Intrauterine Devices: A Decade-Long Retrospective Analysis From a Single Tertiary Center.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Phenotypic heterogeneity in adenomyosis: internal and external subtypes.Archives of gynecology and obstetrics · 2025Observational
- Uterine transverse diameter and risk of LNG-IUS malposition in adenomyosis patients: a threshold effect analysis from a retrospective cohort study.BMC women's health · 2025Article
- The present adenomyosis treatment status in Luzhou, China: a small scope observational cross-sectional survey.BMC women's health · 2025Observational
- Article
- Levonorgestrel-Releasing Intrauterine System Improves Menorrhagia-Related Quality of Life in Patients with Symptomatic Adenomyosis.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- The Effects of Hormonal and Non-Hormonal Intrauterine Devices on Female Sexual Function: A Systematic Review.International journal of sexual health : official journal of the World Association for Sexual Health · 2023Article
- Mirena: Just a contraceptive device? or A modality with diverse clinical applications !Journal of family medicine and primary care · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the levonorgestrel-releasing intrauterine device (LNG-IUD) has been widely applied in the treatment of adenomyosis, not all the patients are satisfied with its efficacy. The present retrospective study aimed to investigate the efficacy of LNG-IUD on different subtypes of adenomyosis.
methodsThe study comprised a cohort of 207 patients who received the LNG-IUD at the Women's Hospital, Zhejiang University School of Medicine, China, from June 2013 to June 2016. Different subtypes of adenomyosis were classified by magnetic resonance imaging (MRI) and patients were subcategorized into three groups (subtype I: intrinsic, n=70; subtype II: extrinsic, n=73; subtype IV: indeterminate, n=64). Multiple variables were compared among the different groups.
resultsPatient demographics, clinical features and the treatment effects of the LNG-IUD were compared between the three subtype groups. The numeric rating scale (NRS) and pictorial blood loss assessment chart (PBAC) score markedly decreased after insertion of the LNG-IUD compared with baseline in all patients in the three subtype groups (P<0.001 for all groups). Compared to the other two subtypes, the efficacy rate was lower and the spontaneous expulsion rate was higher in subtype IV adenomyosis patients than that in other two groups (P<0.05). The independent factor associated with the spontaneous expulsion of the system was suggested to be uterine size before IUD placement and bleeding amount after LNG-IUD treatment in the subtype I [P=0.029, hazards ratio (HR): 3.37, 95% confidence interval (CI): 1.09-6.88] and IV (P=0.045, HR: 1.02, 95% CI: 1.01-1.21) adenomyosis patients respectively.
conclusionsThe LNG-IUD is proved to be an effective approach to treat subtype I and II adenomyosis. However, further study is warranted to explore a more suitable protocol to treat this subtype IV adenomyosis due to the high incidence of treatment failure and expulsion.
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