Evidence map›Paper›PMID 33313066›Full record

ArticleKidney diseases (Basel, Switzerland)2020

Effect of Low-Frequency Therapeutic Ultrasound on Induction of Nitric Oxide in CKD: Potential to Prevent Acute Kidney Injury.

Michael W Dae, Kathleen D Liu, Richard J Solomon, Dong W Gao, Carol A Stillson

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney diseases (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02026544 (Evaluation of the Effect of Low Frequency Therapeutic Ultrasound), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02026544 nacompletednot on this map

Evaluation of the Effect of Low Frequency Therapeutic Ultrasound (LOTUS) on Kidney Function in Chronic Kidney Disease

TypeinterventionalSponsorSonogenixRan2014 to 2014Enrolled10ConditionsChronic Kidney DiseaseArmsLow Frequency Therapeutic Ultrasound
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Michael W DaeDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Kathleen D LiuDivision of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California, USA.
Richard J SolomonDivision of Nephrology and Hypertension, Department of Medicine, The Larner College of Medicine at the University of Vermont, Burlington, Vermont, USA.
Dong W GaoDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Carol A StillsonDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
University of California, San Francisco · USUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPost-contrast acute kidney injury (PC-AKI) develops in a significant proportion of patients with CKD after invasive cardiology procedures and is strongly associated with adverse outcomes.

objectiveWe sought to determine whether increased intrarenal nitric oxide (NO) would prevent PC-AKI.

methodsTo create a large animal model of CKD, we infused 250 micron particles into the renal arteries in 56 ± 8 kg pigs. We used a low-frequency therapeutic ultrasound device (LOTUS - 29 kHz, 0.4 W/cm

resultsIn the pig model, CKD developed over 4 weeks (serum creatinine [Cr], mg/dL, 1.0 ± 0.2-2.6 ± 0.9,

conclusionsLOTUS increased intrarenal NO, RBF, and GFR and prevented PC-AKI in a large animal model of CKD, and significantly increased GFR in patients with CKD. This novel approach may provide a noninvasive nonpharmacological means to prevent PC-AKI in high-risk patients.

Indexed as

Contrast-induced acute kidney injuryLow-frequency ultrasoundNitric oxide

Identifiers

PMID33313066
PMCPMC7706515
OpenAlexW3080476099

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.