Evidence map›Paper›PMID 33313065›Full record

ArticleKidney diseases (Basel, Switzerland)2020

Spectrums and Prognosis of Kidney Disease in Patients with Ankylosing Spondylitis.

Dafeng He, Rong Wang, Shaoshan Liang, Dandan Liang, Feng Xu, Caihong Zeng, Zheng Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney diseases (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Dafeng HeNational Clinical Research Center of Kidney Disease, Jinling Medical College of Nanjing Medical University, Najing, China.
Rong WangNational Clinical Research Center of Kidney Disease, Jinling Medical College of Nanjing Medical University, Najing, China.
Shaoshan LiangNational Clinical Research Center of Kidney Disease, Jinling Medical College of Nanjing Medical University, Najing, China.
Dandan LiangNational Clinical Research Center of Kidney Disease, Jinling Medical College of Nanjing Medical University, Najing, China.
Feng XuNational Clinical Research Center of Kidney Disease, Jinling Medical College of Nanjing Medical University, Najing, China.
Caihong ZengNational Clinical Research Center of Kidney Disease, Jinling Medical College of Nanjing Medical University, Najing, China.
Zheng TangNational Clinical Research Center of Kidney Disease, Jinling Medical College of Nanjing Medical University, Najing, China.
Nanjing Medical University · CNNorthern Jiangsu People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsRenal involvement was a common extra-articular manifestation of ankylosing spondylitis (AS). Few reports have investigated the pathological characteristics and renal outcomes of AS patients with kidney disease. The aim of this study was to investigate the pathological spectrums and the renal prognosis of AS patients with kidney disease.

methodsThis retrospective and observational study was conducted working on 62 patients (47 males and 15 females) with a diagnosis of AS (ACR, 1984) and renal biopsies between 2008 and 2017. The histopathological findings and associated clinical manifestations were collected, and the renal prognoses of patients with kidney disease were evaluated too. Multivariate binary logistic regression analysis was performed to identify risk factors for the occurrence of IgA nephropathy (IgAN).

resultsRenal biopsy revealed that IgAN accounted for a majority (74.2%) of the kidney disease with AS, while membranous nephropathies, minimal change disease, focal segmental glomerulosclerosis, and other lesions accounted for a small minority. Multivariate analysis revealed that serum immunoglobulin A >3.45 g/L and immunoglobulin G >9.06 g/L were risk factors for the occurrence of IgAN. With a median follow-up time of 24.3 months, 28 patients (50.9%) reached complete remission, 9 patients (16.4%) had partial remission, and 1 patient had an eGFR decline >30%. No difference was found in prognosis between IgAN and non-IgAN.

conclusionIgAN occurred in 76.4% of the kidney disease with AS, and higher serum immunoglobulin A and G increased the risk for the occurrence of IgAN. The renal prognosis of kidney disease in AS was good.

Indexed as

Ankylosing spondylitisIgA nephropathyKidneyPathological spectrumsPrognosis

Identifiers

PMID33313065
PMCPMC7706489
OpenAlexW3080205114

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.