Evidence map›Paper›PMID 33312857›Full record

ArticleRespiratory medicine case reports2020

Effect of everolimus on multifocal micronodular pneumocyte hyperplasia in tuberous sclerosis complex.

Cécile Daccord, Aymeric Nicolas, Rita Demicheli, Hassib Chehade, Andreas F Hottinger, Catherine Beigelman, Romain Lazor

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory medicine case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Cécile DaccordDepartment of Respiratory Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
Aymeric NicolasDepartment of Radiodiagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
Rita DemicheliDepartment of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
Hassib ChehadeDepartment Woman-Mother-Child, Division of Paediatrics, Paediatric Nephrology Unit, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
Andreas F HottingerDepartment of Oncology, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
Catherine BeigelmanDepartment of Radiodiagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
Romain LazorDepartment of Respiratory Medicine, Lausanne University Hospital (CHUV) and University of Lausanne, Switzerland.
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multifocal micronodular pneumocyte hyperplasia (MMPH) is a benign proliferation of alveolar type II cells presenting as multiple pulmonary nodules at chest imaging, which is frequently seen in patients with tuberous sclerosis complex (TSC). We report a case of a woman with TSC and MMPH who received everolimus, a mechanistic target of rapamycin (mTOR) inhibitor, for the treatment of a subependymal giant cell astrocytoma (SEGA). After 3 months of therapy, a remarkable decrease in density of all pulmonary MMPH lesions was observed, without any change in size. This shows that everolimus is active on MMPH similarly to its effects on SEGA, renal angiomyolipomas, and pulmonary lymphangioleiomyomatosis in TSC, and suggests that the dysregulated activation of mTOR which characterizes TSC also plays a role in the pathogenesis of MMPH.

Indexed as

Alveolar epithelial cellsEverolimusLungMechanistic target of rapamycinMultifocal micronodular pneumocyte hyperplasiaTuberous sclerosis

Identifiers

PMID33312857
PMCPMC7720070
OpenAlexW3107557487

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.