ArticleTranslational neuroscience2020
Deviant cortical sulcation related to schizophrenia and cognitive deficits in the second trimester.
Article in Translational neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Review
- Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations.AIMS neuroscience · 2024Article
- Prognostic associations of cortical gyrification in minimally medicated schizophrenia in an early intervention setting.Schizophrenia (Heidelberg, Germany) · 2022Article
- Aberrant cortical surface and cognition function in drug-naive first-episode schizophrenia.Annals of general psychiatry · 2022Article
- Structural Covariance of Cortical Gyrification at Illness Onset in Treatment Resistance: A Longitudinal Study of First-Episode Psychoses.Schizophrenia bulletin · 2021Article
- Symptom-Related Differential Neuroimaging Biomarkers in Children with Corpus Callosum Abnormalities.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
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Authors and funding
3 authors.
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Abstract
objectivesAberrant cortical development, inferred from cortical folding, is linked to the risk of schizophrenia. Cortical folds develop in a time-locked fashion during fetal growth. We leveraged this temporal specificity of sulcation to investigate the timing of the prenatal insult linked to schizophrenia and the cognitive impairment seen in this illness.
methodsAnatomical MRI scans from 68 patients with schizophrenia and 72 controls were used to evaluate the sulcal depth of five major invariable primary sulci representing lobar development (calcarine sulcus, superior temporal sulcus, superior frontal sulcus, intraparietal sulcus and inferior frontal sulcus) with formation representing the distinct developmental periods.
resultsA repeated-measure ANOVA with five sulci and two hemispheres as the within-subject factors and gender, age and intracranial volume as covariates revealed a significant effect of diagnosis (
conclusionOur results suggest that the gestational disruption underlying schizophrenia is likely to predate, if not coincide with the appearance of calcarine sulcus (early second trimester). Nevertheless, the burden of cognitive deficits may relate specifically to the aberrant superior frontal development apparent in late second trimester.
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