ArticleFood science & nutrition2020
Effect of astragaloside on diaphragm cell apoptosis in chronic obstructive pulmonary disease.
Article in Food science & nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed, 6 citations in OpenAlex.
- An Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometric Method for the Simultaneous Determination of Eighteen Marker Compounds in the Traditional Herbal Formula Bopyeo-Tang.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Effect of astragaloside on diaphragm cell apoptosis in chronic obstructive pulmonary disease.Food science & nutrition · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study aimed to discuss the effects and relative mechanisms of astragaloside (AST) on diaphragm cell apoptosis in mice with chronic obstructive pulmonary disease (COPD). MATERIALS AND
methodsThe mouse models of COPD were established by passive smoking. The pathological changes in lung and diaphragm tissues were observed by hematoxylin and eosin staining and evaluating the number of apoptotic cells of the diaphragm via a terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. The relative protein expression levels of AKT, p-AKT, caspase-3, and caspase-9 were measured through immunohistochemistry and Western blot assay.
resultsIn comparison with the normal control mice, the pathological change and number of apoptotic cells deteriorated in the lung and diaphragm tissues of COPD model mice. With AST supplement, the pathological change and the number of apoptotic cells significantly improved (
conclusionOur in vivo study revealed that AST improved COPD-induced diaphragm apoptosis by regulating and depressing AKT activities.
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Registered trials
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