ArticleAmerican journal of translational research2020
Downregulation of SENP1 suppresses LPS-induced macrophage inflammation by elevating Sp3 SUMOylation and disturbing Sp3-NF-κB interaction.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 12 citations in OpenAlex.
- Diabetic retinopathy: shaped by the "hidden hand" of post-translational modifications.Molecular neurodegeneration · 2026Review
- Biomarker value of plasma endothelial microvesicle-derived circRNA 0006222 in vascular ageing and carotid atherosclerosis.Frontiers in neuroscience · 2026Article
- SENP1: A perspective from immune cells to disease (Review).Oncology reports · 2025Review
- Effects and molecular mechanisms ofFrontiers in pharmacology · 2025Review
- Post-translational modifications in sepsis-induced organ dysfunction: mechanisms and implications.Frontiers in immunology · 2024Review
- Roles of protein post-translational modifications in glucose and lipid metabolism: mechanisms and perspectives.Molecular medicine (Cambridge, Mass.) · 2023Review
- SENP1 Protects Against Pressure Overload-Induced Cardiac Remodeling and Dysfunction Via Inhibiting STAT3 Signaling.Journal of the American Heart Association · 2022Article
- Extracellular histones induce inflammation and senescence of vascular smooth muscle cells by activating the AMPK/FOXO4 signaling pathway.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Identification of selection signatures in Iranian dromedary and Bactrian camels using whole genome sequencing data.Scientific reports · 2022Article
- Ginkgolic acid promotes inflammation and macrophage apoptosisFrontiers in medicine · 2022Article
- Hypoxia- and Inflammation-Related Transcription Factor SP3 May Be Involved in Platelet Activation and Inflammation in Intracranial Hemorrhage.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Macrophages participate in all stages of sepsis and affect immune homeostasis and inflammatory processes. Small ubiquitin-like modifier (SUMO) protease SENP1 plays an important role in cellular inflammation by regulating proteins in SUMOylation. However, the roles and related mechanisms of SENP1 in macrophage inflammation during sepsis are largely unknown. In the present study, SENP1 expression was significantly promoted in lipopolysaccharide (LPS)-induced RAW 264.7 cells; furthermore, the knock down of SENP1 reduced the expression of inflammatory cytokines interleukin-6 and tumor necrosis factor-α. Momordin Ic (MC), a new type of SENP1 inhibitor, reduces LPS-induced cellular inflammation by depressing SENP1 expression. Moreover, the effect of SENP1 on LPS-induced inflammatory response was dependent on SENP1-Sp3 interaction and the promotion of Sp3 expression via Sp3 deSUMOylation. Furthermore, MC-depressed Sp3 expression disturbed Sp3-nuclear factor (NF)-κB interaction and then alleviated LPS-induced cellular inflammation. These results suggest that SENP1 promotes LPS-induced macrophage inflammation by promoting Sp3 expression via deSUMOylation and Sp3-NF-κB interaction in sepsis.
Indexed as
Identifiers
33312380PMC7724363W3117082504What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.