ArticleAmerican journal of translational research2020
Assessment of hazard immune-related genes and tumor immune infiltrations in renal cell carcinoma.
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- UNC93B1: a novel immune-related prognostic biomarker in breast cancer.Discover oncology · 2025Article
- NUDT21 interacts with NDUFS2 to activate the PI3K/AKT pathway and promotes pancreatic cancer pathogenesis.Journal of cancer research and clinical oncology · 2024Article
- Machine Learning-based Framework Develops a Tumor Thrombus Coagulation Signature in Multicenter Cohorts for Renal Cancer.International journal of biological sciences · 2024Article
- SLA2 is a prognostic marker in HNSCC and correlates with immune cell infiltration in the tumor microenvironment.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- CD72, a new immune checkpoint molecule, is a novel prognostic biomarker for kidney renal clear cell carcinoma.European journal of medical research · 2023Article
- Identification and validation of a novel anoikis-related long non-coding RNA signature for pancreatic adenocarcinoma to predict the prognosis and immune response.Journal of cancer research and clinical oncology · 2023Article
- PPP1R14B is a diagnostic prognostic marker in patients with uterine corpus endometrial carcinoma.Journal of cellular and molecular medicine · 2023Article
- Increased expression of NOP14 is associated with improved prognosis due to immune regulation in colorectal cancer.BMC gastroenterology · 2022Article
- Identification of miRNA-mRNA network and immune-related gene signatures in IgA nephropathy by integrated bioinformatics analysis.BMC nephrology · 2021Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present study aimed to explore and validate a prognostic immune signature, to formulate a prognosis for ccRCC patients combined with immune-infiltration analysis.
methodsPublic datasets were used as our source of multi-omics data. Differential analysis was performed via the edgeR package. A prognostic immune signature was identified by univariate Cox analysis, and we constructed an integrative tumor-associated immune genes (TAIG) model from the multivariate Cox results. In order to interrogate and identify the related crosstalk, functional analysis was deployed. Significantly, we implemented the CIBERSORT algorithm to estimate the immune cell fractions in the ccRCC samples, and analyzed the differential abundance of tumor-infiltrating immune cells in two TAIG groups, using a Wilcoxon rank-sum test. The prognostic role of differential immune cells was further assessed via a Kaplan-Meier analysis. In addition, we investigated the associations of a single immune signature with specific immune cells.
resultsA total of 628 ccRCC patients were comprised in our integrative analysis, including 537 ccRCC patients in the discovery group and 91 patients in the validation group. Fourteen key immune signatures were subsequently identified. A figure of 0.802 was registered for AUC, and worse prognosis was evinced for those patients with a higher TAIG. Correlation analysis indicated that TAIG correlated closely with both clinical variables and TMB. Moreover, functional analysis implicated the immune-related GO items or crosstalk. Hence, we were able to identify the relationships obtaining between tumor-infiltrating immune cells and TAIG. The differential abundance of immune cells showed a significant prognostic difference and consisted of memory-activated CD4
conclusionsOverall, our team characterized the tumor-associated immune signature in ccRCC, and further identified the prognostic tumor-infiltrating immune cells related to TAIG. This in turn provided a solid foundation for investigating individualized immunotherapy, as well as other relevant mechanisms.
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