Evidence map›Paper›PMID 33312174›Full record

ArticleFrontiers in immunology2020

An Immunomodulatory Gallotanin-Rich Fraction From

Paola Lasso, Alejandra Gomez-Cadena, Claudia Urueña, Alena Donda, Amaia Martinez-Usatorre, Pedro Romero, Alfonso Barreto, Susana Fiorentino

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Pooled it
  2. Myeloid-derived suppressor cells modulation in the context of tumor microenvironment for gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Review
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  13. Cancers · 2022
    Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Paola LassoGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.
Alejandra Gomez-CadenaGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.
Claudia UrueñaGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.
Alena DondaUniversity of Lausanne, Department of Fundamental Oncology, Lausanne, Switzerland.
Amaia Martinez-UsatorreSwiss Federal Institute of Technology Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland.
Pedro RomeroUniversity of Lausanne, Department of Fundamental Oncology, Lausanne, Switzerland.
Alfonso BarretoGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.
Susana FiorentinoGrupo de Inmunobiología y Biología Celular, Pontificia Universidad Javeriana, Bogotá, Colombia.
Pontificia Universidad Javeriana · COUniversity of Lausanne · CHÉcole Polytechnique Fédérale de Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are reduced to a group of patients. The research in combined therapies, which allow for a greater response, is strongly encouraging. We previously characterized a polyphenol-rich extract from

Indexed as

AnimalsAntibodies, MonoclonalAntineoplastic AgentsB7-H1 AntigenBreast NeoplasmsCaesalpiniaCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesCell Line, TumorCell ProliferationFemaleHumansHydrolyzable TanninsImmunityImmunologic FactorsMCF-7 CellsAntibodies, MonoclonalAntineoplastic AgentsB7-H1 AntigenCd274 protein, mouseHydrolyzable TanninsImmunologic FactorsPlant ExtractsPolyphenolsbreast cancercombined therapyimmunotherapymelanomanatural productsP2Et extractPD-L1

Identifiers

PMID33312174
PMCPMC7708328
OpenAlexW3106058410

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.