Evidence map›Paper›PMID 33312107›Full record

ArticleEXCLI journal2020

Genome-wide expression changes induced by bisphenol A, F and S in human stem cell derived hepatocyte-like cells.

B Lucendo-Villarin, P Nell, B Hellwig, P Filis, D Feuerborn, P J O'Shaughnessy, P Godoy, J Rahnenführer, J G Hengstler, A Cherianidou and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EXCLI journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

B Lucendo-VillarinCentre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
P NellIfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.
B HellwigDepartment of Statistics, Technical University Dortmund, Dortmund, Germany.
P FilisInstitute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
D FeuerbornIfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.
P J O'ShaughnessyInstitute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, UK.
P GodoyIfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.
J RahnenführerDepartment of Statistics, Technical University Dortmund, Dortmund, Germany.
J G HengstlerIfADo-Leibniz Research Centre for Working Environment and Human Factors at the Technical University Dortmund, Dortmund, Germany.
A CherianidouInstitute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne (UKK), Cologne, Germany.
A SachinidisInstitute of Neurophysiology and Center for Molecular Medicine Cologne (CMMC), University of Cologne (UKK), Cologne, Germany.
P A FowlerInstitute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
D C HayCentre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK.
TU Dortmund University · DELeibniz Research Centre for Working Environment and Human Factors · DEUniversity of Aberdeen · GBUniversity of Cologne · DEUniversity of Edinburgh · GBUniversity of Glasgow · GB

Funding

Chief Scientist Office TCS/16/37
6 · The paper itself

Abstract

The debate about possible adverse effects of bisphenol A (BPA) has been ongoing for decades. Bisphenol F (BPF) and S (BPS) have been suggested as "safer" alternatives. In the present study we used hepatocyte-like cells (HLCs) derived from the human embryonic stem cell lines Man12 and H9 to compare the three bisphenol derivatives. Stem cell-derived progenitors were produced using an established system and were exposed to BPA, BPF and BPS for 8 days during their transition to HLCs. Subsequently, we examined cell viability, inhibition of cytochrome P450 (CYP) activity, and genome-wide RNA profiles. Sub-cytotoxic, inhibitory concentrations (IC

Indexed as

bisphenol Abisphenol Fbisphenol Shepatocyte-like cellsliverpluripotent stem cell

Identifiers

PMID33312107
PMCPMC7726493
OpenAlexW3117996438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.